336-59-4 Usage
Uses
Used in Gas Chromatography (GC) Applications:
Heptafluorobutyric anhydride is used as a GC derivatizing agent for the preparation of volatile derivatives of amino acids and other biologically active compounds. It increases the volatility of an analyte and introduces fluorine atoms for better detection limits in GC applications.
Used in Derivatization of Primary and Secondary Amines:
HFAA is frequently used as an acylating agent for the derivatization of primary and secondary amines. It helps in the formation of stable, volatile derivatives, which are useful for gas chromatographic analyses.
Used in Suzuki Reaction:
Heptafluorobutyric anhydride is used in the Suzuki reaction, a type of organoboron cross-coupling reaction, to form stable, volatile derivatives that can be analyzed using gas chromatography.
Used in Gas Chromatography Mass Spectrometry (GC-MS) Analysis:
HFAA is used as a derivatization reagent for GC-MS analysis of the stereoisomer content of synthetic peptides. It helps in the preparation of volatile derivatives that can be easily analyzed using this technique.
Used in Drug Testing:
Heptafluorobutyric anhydride is also used for the frequent testing of drugs of abuse, such as amphetamines and phencyclidine, by the GC-MS technique. It aids in the preparation of volatile derivatives that can be easily detected and analyzed.
Check Digit Verification of cas no
The CAS Registry Mumber 336-59-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 336-59:
(5*3)+(4*3)+(3*6)+(2*5)+(1*9)=64
64 % 10 = 4
So 336-59-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H7F7O3/c1-2-18-5(17)3-4(16)6(9,10)7(11,12)8(13,14)15/h2-3H2,1H3
336-59-4Relevant academic research and scientific papers
Hydroxy protection groups
-
, (2008/06/13)
The present invention concerns a method for preparing unprotected hydroxy compounds or acylated derivatives thereof by conversion of silyl alkyl-protected hydroxy compounds. The invention also relates to novel intermediates useful in the method and for other purposes.
Reaction of Bis(heptafluorobutyryl) Peroxide with Carbanions and a Thiolate Anion
Yoshida, Masato,Shimokoshi, Kazuaki,Kobayashi, Michio
, p. 433 - 436 (2007/10/02)
In the reaction of bis(heptafluorobutyryl) peroxide with carbanions and a thiolate anion, two types of reactions were observed; one is an electron transfer reaction to give perfluoropropylated compounds and the other is a nucleophilic substitution.
