33602-03-8

Usage

Uses

Used in Personal Care and Household Products:
1-(1-Oxodecyl)-2-pyrrolizinone is used as a surfactant and emulsifier for its ability to lower surface tension and improve the spreadability and stability of formulations. This makes it a valuable component in the production of personal care and household products, enhancing their performance and user experience.
Used in Skincare Products:
In the skincare industry, 1-(1-Oxodecyl)-2-pyrrolizinone is utilized for its antimicrobial and antioxidant properties. These characteristics contribute to the compound's effectiveness in promoting skin health and protecting products from microbial contamination, ensuring a longer shelf life and improved safety for consumers.
Used in Industrial Applications:
Beyond personal care and skincare, 1-(1-Oxodecyl)-2-pyrrolizinone also finds use in various industrial applications. Its surfactant and emulsifier properties are beneficial in the manufacturing process of different products, where it can improve the efficiency of mixing and the quality of the final product.
It is crucial to handle 1-(1-Oxodecyl)-2-pyrrolizinone with care and adhere to safety guidelines, as it may pose hazards if mismanaged.

Upstream product

• 616-45-5 2-pyrrolidinon 
• 112-13-0 n-decanoyl chloride 
• 70974-43-5 1-(pyrrolidin-1-yl)decan-1-one 

Relevant academic research and scientific papers

Oxidation of N-acyl-pyrrolidines to imides with CrO3·3,5- dimethylpyrazole

N-Acyl-pyrrolidones are easily obtained by treatment of N-acyl- pyrrolidines with CrO33,5-dimethylpyrazole complex (CrO33,5-DMP) at room temperature.

Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives

Several 1-acyl-2-pyrrolidinone derivatives were synthesized as derivatives of γ-aminobutyric acid (GABA), and their pharmacological activities and stabilities were investigated. The derivatives showed anticonvulsant effect on picrotoxin-induced seizure at a dose of 200 mg/kg. In particular, 1-decanoyl-2-pyrrolidinone (7) and 1-dodecanoyl-2-pyrrolidinone (8) had a high activity. The anticonvulsant activity showed a dose dependency. Some of 1-acyl-2-pyrrolidinone derivatives prolonged sleeping time which was induced by sodium pentobarbital and showed a recovery from disruption of the memory of passive avoidance response, which was induced by an electroconvulsive shock. As shown by the results of the stability study of 1-acetyl-2-pyrrolidinone (1), it was degraded in an acidic buffer and an alkaline buffer although 2-pyrrolidinone was stable. 1-Acyl-2-pyrrolidinone derivatives were degraded in liver and brain homogenates of mouse and rat. They showed a degradation rate in rat plasma. Conversion of 8 to GABA in mouse liver homogenate was demonstrated. These results suggested that the pharmacological activity of 1-acyl-2-pyrrolidinone is probably due to the release of GABA by hydrolysis of derivatives although further work is necessary.