33605-76-4

Basic information

• Product Name: FOR-ASP-PHE-OME
• Synonyms: FORMYL ASPARTAME;FOR-ASP-PHE-OME;1-methyl N-(N-formyl-L-alpha-aspartyl)-3-phenyl-L-alaninate;CHO-L-Asp-L-Phe-OMe;For-L-Asp-L-Phe-OMe;N-Formyl-L-αAsp-L-Phe-OMe;N-Formyl-alpha-aspartylphenylalanine methyl ester;N-Formyl-alpha-L-aspartyl-L-phenylalanine methyl ester
• CAS NO: 33605-76-4
• Molecular Formula: C₁₅H₁₈N₂O₆
• Molecular Weight: 322.31
• EINECS: 251-590-3
• Mol File: 33605-76-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 138-141℃
• Boiling Point: 643.513 °C at 760 mmHg
• Flash Point: 342.985 °C
• Appearance: /
• Density: 1.295
• CAS DataBase Reference: FOR-ASP-PHE-OME(CAS DataBase Reference)
• NIST Chemistry Reference: FOR-ASP-PHE-OME(33605-76-4)
• EPA Substance Registry System: FOR-ASP-PHE-OME(33605-76-4)

Safety Data

• Hazardous Substances Data: 33605-76-4(Hazardous Substances Data)

Usage

General Description

FOR-ASP-PHE-OME is a chemical compound consisting of the amino acids phenylalanine, aspartic acid, and a formyl group. It is commonly used as a building block in peptide synthesis and pharmaceutical research. The presence of the formyl group allows for selective modification of the peptide, making it a valuable tool in chemical biology and drug development. FOR-ASP-PHE-OME has also been studied for its potential anti-inflammatory and analgesic properties, making it a promising candidate for the development of new medications. Its unique chemical structure and diverse pharmacological properties make it a versatile and important compound in the field of medicinal chemistry.

Upstream product

• 19427-28-2 N-formyl-L-aspartic acid 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 116147-62-7 n-formyl-l-aspartic anhydride 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 100101-47-1 (Z)-N-(N-formyl-α-L-aspartyl)-Δ-phenylalanine methyl ester 
• 33605-73-1 N-(2,5-Dioxo-tetrahydro-furan-3-yl)-formamide 
• 2577-90-4 L-phenylalanine methyl ester 

Downstream Products

• 22839-47-0 L-Asp-L-Phe-OMe 
• 5910-52-1 α-L-aspartyl-L-phenylalanine methyl ester hydrochloride 

Relevant articles and documents

Preparation of N-protected α-L-aspartyl-L-phenylalanine methyl ester

Disclosed is an improved process for the preparation of an N-protected α-L-aspartyl-L-phenylalanine methyl ester from an N-protected L-aspartic anhydride and L-phenylalanine methyl ester, the improvement which comprises employing the L-phenylalanine methyl ester in the form of a mineral acid salt thereof and conducting the reaction either (a) in an organic solvent and in the presence of a salt of an organic carboxylic acid, or (b) in an organic solvent comprising an organic carboxylic acid and in the presence of at least one member of the group consisting of an alkali metal or an alkaline earth metal inorganic base, an ammonium alkali metal or alkaline earth metal salt of an organic carboxylic acid and ammonium carbonate. The starting N-protected aspartic anhydride, e.g., N-benzyloxycarbonyl-L-aspartic anhydride, can be produced by the reaction of N-protected aspartic acid with phosgene. When the N-protecting group sibenzyloxycarbonyl and the solvent is acetic acid, the desired product can be isolated from the reaction mixture in crystalline form in high purity by adding water thereto.

Untersuchungen zum Einfluss verschiedener Reaktionsparameter auf die Synthese von N-Formylaspartam

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Synthesis of Aspartame via Asymmetric Hydrogenation of N-Protected (Z)-N-α-L-Aspartyl-Δ-phenylalanine Methyl Ester

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