5910-52-1

Basic information

• Product Name: 1-methyl N-L-alpha-aspartyl-3-phenyl-L-alaninate monohydrochloride
• Synonyms: 1-methyl N-L-alpha-aspartyl-3-phenyl-L-alaninate monohydrochloride
• CAS NO: 5910-52-1
• Molecular Formula: C₁₄H₁₈N₂O₅*ClH
• Molecular Weight: 330.76406
• EINECS: 227-623-2
• Mol File: 5910-52-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-methyl N-L-alpha-aspartyl-3-phenyl-L-alaninate monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl N-L-alpha-aspartyl-3-phenyl-L-alaninate monohydrochloride(5910-52-1)
• EPA Substance Registry System: 1-methyl N-L-alpha-aspartyl-3-phenyl-L-alaninate monohydrochloride(5910-52-1)

Safety Data

• Hazardous Substances Data: 5910-52-1(Hazardous Substances Data)

Usage

Explanation

This is the chemical name of the compound, which is a dipeptide derivative.

Explanation

The compound has potential uses in the pharmaceutical industry due to its possible therapeutic effects.

Explanation

It is derived from two amino acids and has potential therapeutic properties.

Explanation

The compound may help reduce inflammation and relieve pain in the body.

Explanation

Studies have been conducted on the compound for its potential use in managing long-term pain and inflammation.

Explanation

The monohydrochloride form of the compound makes it suitable for pharmaceutical applications.

Explanation

Further research and development of 1-methyl N-L-alpha-aspartyl-3-phenyl-L-alaninate monohydrochloride may lead to the creation of new medications for a range of health issues.

Industry

Pharmaceutical

Classification

Dipeptide derivative

Potential effects

Anti-inflammatory and analgesic

Applications

Treatment of chronic pain and inflammatory conditions

Form

Monohydrochloride

Future development

New drugs for various medical conditions

Upstream product

• 22839-82-3 N-α-L-aspartyl-L-phenylalaninemethyl ester 
• 63-91-2 L-phenylalanine 
• 4976-94-7 Boc-Asp(OtBu)-Phe-OMe 
• 33605-76-4 N-formylaspartame 
• 41567-23-1 anhydride du N-chloroacetyl-L-acide aspartique 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 67-56-1 methanol 

Downstream Products

• 22839-47-0 L-Asp-L-Phe-OMe 

Relevant articles and documents

METHOD FOR THE SYNTHESIS OF PEPTIDES WITHOUT SOLVENT

The disclosure relates to a method for the synthesis of a compound of the formula (I) in which: n is an integer higher than or equal to 1; Rb and each Rn are independently a hydrogen atom, a C1-C6 arylalkyl group or a C1-C6 alkyl group substituted or not by an aryl group, —COOH, C1-C6, —COO-(alkyl), —CONH2, —SH, heteroaryl, —NH2, —NHC(NH)(NH2), C1-C6-s-(alkyl), —OH or phenol; Ra is a N-protective group; Rc is a ORd group in which Rd is a C1-C6 alkyl group or a NReRf group in which Re and Rf Re independently an N-protective group.

Solvent-free synthesis of peptides

Chamical Equation Presentation A crush on sweetness! The coupling of a urethane-protected N-carboxyanhydride of an amino acid with another amino acid derivative under ball-milling conditions gives a protected dipeptide in very high yield (see scheme; PG: protecting group). The reaction takes place in the solid state. The synthesis was applied to the preparation of a tri peptide and the sweetener aspartame, without any organic solvent or purification.

Process for the preparation of alfa-L-aspartyl-L-phenyl-alanine alkyl esters

A new process for preparing alfa-L-aspartyl-L-phenylalanine alkyl esters of formula I STR1 wherein R represents an alkyl group having from 1 to 5 carbon atoms, starting from the corresponding alfa-haloacyl-alfa-L-aspartyl-L-phenylalanine alkyl esters.

Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester

A regioselective process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester is disclosed. A controlled aqueous coupling reaction between β-methyl-L-aspartate-N-carboxyanhydride and L-phenylalanine produces the aspartyl methyl ester of α-L-aspartyl-L-phenylalanine which is subsequently hydrolyzed and selectively esterified without isolation. The hydrochloride salt of α-L-aspartyl-L-phenylalanine methyl ester, which is selectively precipitated from the esterification mixture, can be neutralized to α-L-aspartyl-L-phenylalanine methyl ester.

Method of removing formyl groups from N-formyl-amino acid and N-formyl-peptide esters having free carboxyl groups

The masking N-formyl group of an N-formyl-amino acid ester or an N-formyl-peptide ester having a free carboxyl group is removed without major side reactions when the ester is contacted with a strong acid in a mixture of water and a specific organic solvent such as methyl ethyl ketone or acetonitrile. This method is specifically applicable to the production of L-aspartyl amino acid lower alkyl esters which are known as low calorie sweeteners.

Method of removing formyl groups from N-formyl-amino acid and N-formyl-peptide esters

The masking N-formyl group of an N-formyl-amino acid ester or N-formyl-peptide ester is removed without major side reactions when the ester is reacted in an inert liquid medium with hydroxylamine of which at least 70% is present in the form of a salt with a strong acid, the remainder, if any, being present as the free base or the salt of a weak acid.