33609-68-6Relevant academic research and scientific papers
Copper-mediated C(sp3)-H azidation with Me3SiN3: Synthesis of imidazoles from ketones and aldehydes
Xie, Zeqiang,Deng, Jiaojiao,Qiu, Zhiping,Li, Juan,Zhu, Qiang
supporting information, p. 6467 - 6470 (2016/05/24)
The efficient construction of 2,4,5-trisubstituted imidazoles, through a copper-mediated three-component reaction involving ketones, aldehydes, and Me3SiN3, has been developed. During the process, 4 C-N bonds were formed sequentially. Experimental results and DFT calculations suggested that azidation of the alpha methylene group of the ketone was the key C-N bond-forming step.
