3361-69-1

Upstream product

• 717-74-8 1,3,5-triisopropyl benzene 

Downstream Products

• 108-73-6 3,5-dihydroxyphenol 
• 19576-38-6 1,3,5-tri(2-hydroxyisopropyl)benzene 
• 19576-37-5 1,3-bis-(α-hydroxy-isopropyl)-5-isopropyl-benzene 
• 114063-31-9 1,3,5-tris-(α-carboxymethylsulfanyl-isopropyl)-benzene 
• 77367-66-9 1,3,5-tris(1-chloro-1-methylethyl)benzene 

Relevant academic research and scientific papers

Synthesis method of high-purity phloroglucinol compound

The invention discloses a one-step chemical catalytic synthesis method of high-purity phloroglucinol by taking 3,5-dichlorophenol as a starting material and taking strong base and a catalyst as auxiliary materials. Through the method, the phloroglucinol compound with high molar yield, high purity and low cost can be effectively synthesized.

METHOD FOR THE SYNTHESIS OF INITIATORS FOR TELECHELIC POLYISOBUTYLENES

A new methodology for the synthesis of a novel difunctional- and a known trifunctional initiator, i.e., 1,3-di(2-methoxy-2-propyl)-5-isopropyl benzene and 1,3,5-tri(2-methoxy-2-propyl) benzene, respectively, for the preparation of di- and tri-telechelic polyisobutylenes. The synthesis proceeds in three steps: 1) catalytic peroxidation of 1,3,5-triisopropylbenzene, 2) reduction of the peroxides to the corresponding alcohols, and 3) methylation of the alcohols. By controlling the conversion of the key peroxidation step the relative ratio of di- and tri-fiinctional intermediates can be controlled. By the use of the 1,3-di(2-methoxy-2-propyl)-5-isopropyl-benzene, well-defined di-methoxy telechelic polyisobutylenes can be synthesized. Although the overall combined yield of the two initiators was only 14-20%, because of the low cost of the starting material, reagents used, and simple manipulations these compounds represent the most cost effective initiators to-date for the preparation of telechelic polyisobutylenes.

Aerobic oxidation of 1,3,5-triisopropylbenzene using N-hydroxyphthalimide (NHPI) as key catalyst

The first systematic study on the aerobic oxidation of 1,3,5- triisopropylbenzene was examined by the use of N-hydroxyphthalimide (NHPI) as a key catalyst. It was found that 1,3,5-triisopropylbenzene was efficiently oxidized with O2 in the presence of a catalytic amount of NHPI and azobisisobutyronitrile (AIBN) at 75°C. Upon treatment of the resulting products with sulfuric acid followed by acetic anhydride led to 5-acetoxy-1,3-diisopropylbenzene and 3,5-diacetoxy-1-isopropylbenzene as major products and a small amount of 1,3,5-triacetoxybenzene. When t-butylperoxypivalate (BPP) was employed as a radical initiator, the oxidation could be achieved in good yield even at 50°C. This oxidation provides a facile method for preparing phenol derivatives bearing an isopropyl moiety, which can be used as pharmaceutical starting materials.