336106-22-0Relevant academic research and scientific papers
NEW BENZIMIDAZOLE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS
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Page/Page column 80; 82, (2019/09/12)
The present invention encompasses compounds of formula (I) (I), wherein the groups R1 to R5 have the meanings given in the claims and specification, their use as inhibitors of mutant EGFR, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Intermediacy of an N-heterocyclic carbene complex in the catalytic C-H activation of a substituted benzimidazole
Tan, Kian L.,Bergman, Robert G.,Ellman, Jonathan A.
, p. 3202 - 3203 (2007/10/03)
An N-heterocyclic carbene complex was found to be the active catalyst in the Rh(I)-catalyzed intramolecular coupling of an alkenyl group to a C-H bond of a substituted benzimidazole. Kinetic studies demonstrated that the catalytic cyclization is zero-orde
