33611-43-7

Basic information

• Product Name: METHYL 3-MORPHOLINOPROPIONATE
• Synonyms: AI3-23312;4-morpholinepropanoicacid,methylester;Methyl 3-(4-morpholinyl)propanoate;AKOS BB-8700;3-(N-MORPHOLIN)PROPANOIC ACID METHYL ESTER;3-MORPHOLINYL METHYL PROPIONATE;METHYL 3-MORPHOLIN-4-YLPROPANOATE;METHYL 3-MORPHOLINOPROPIONATE
• CAS NO: 33611-43-7
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.21
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Morpholines
• Mol File: 33611-43-7.mol
• Article Data: 63

Chemical Properties

• Boiling Point: 82 °C2 mm Hg(lit.)
• Flash Point: 220 °F
• Appearance: /
• Density: 1.068 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0213mmHg at 25°C
• Refractive Index: n20/D 1.459(lit.)
• PKA: 5.98±0.10(Predicted)
• CAS DataBase Reference: METHYL 3-MORPHOLINOPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-MORPHOLINOPROPIONATE(33611-43-7)
• EPA Substance Registry System: METHYL 3-MORPHOLINOPROPIONATE(33611-43-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 33611-43-7(Hazardous Substances Data)

Usage

Uses

Methyl 3-Morpholin-4-ylpropanoate is used in method for preparation steric hindrance adjustable weak base light stabilizers with effective light stability and antioxidation stability protection for polymer material.

InChI:InChI=1/C8H15NO3/c1-11-8(10)2-3-9-4-6-12-7-5-9/h2-7H2,1H3

Upstream product

• 110-91-8 morpholine 
• 6001-87-2 methyl 3-chloropropionate 
• 292638-85-8 acrylic acid methyl ester 
• 100-46-9 benzylamine 
• 141-97-9 ethyl acetoacetate 
• 75-31-0 isopropylamine 

Downstream Products

• 4497-04-5 3-morpholin-4-ylpropionic acid 
• 55716-11-5 perfluoro(N-ethylmorpholine) 
• 358-21-4 perfluorodiethyl ether 
• 382-28-5 2,2,3,3,5,5,6,6-Octafluoro-4-trifluoromethyl-morpholine 
• 124008-14-6 perfluoro-(3-morpholinopropionyl fluoride) 
• 59737-33-6 3-(morpholin-4-yl)propionic acid hydrazide 
• 1026701-62-1 4-morpholin-4-yl-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butan-2-ol 

Relevant articles and documents

Ni(II) complexes containing chiral tridentate phosphines as new catalysts for the hydroamination of activated olefins

Ni(II) complexes containing chiral tridentate ferrocenyl phosphines (Ni(PPP)) have been found to efficiently catalyse the hydroamination of activated olefins with both anilines and aliphatic amines at r.t. (TON up to 71, TOF up to ca. 3 h-1, and enantioselectivities up to 69% ee).

A Commercially Available and User-Friendly Catalyst for Hydroamination Reactions under Technical Conditions

The activity of a simple, commercially available copper salt, [Cu(NCMe)4](BF4) in intramolecular hydroamination reactions of alkynes and allenes is presented. Reactions were successfully carried out in technical acetonitrile in the presence of air. While attempts of alkene hydroamination failed, this catalyst was also found active in intermolecular aza-Michael reactions.

Cultivation of a Cu/HMPC catalyst from a hyperaccumulating mustard plant for highly efficient and selective coupling reactions under mild conditions

Cu-containing activated carbon (eco-catalyst, Cu/HMPC, where 'C' defines 'carbon') was derived from a metal-hyperaccumulating mustard plant (HMP) by a simple chemical activation method. Transmission electron microscopy/selected area diffraction (HRTEM/SAED) results revealed that the Cu/HMPC has mainly three types of morphology [sheet-like morphology (2D), hollow-spheres (3D) and needle-like structures (1D)] which are interconnected. HRTEM-SAED, Raman and X-ray photoelectron spectroscopy (XPS) results confirmed the existence of Cu oxide species in Cu/HMPC. Content of Cu in Cu/HMPC was determined to be 1.03 wt%. The quality of graphitization in Cu/HMPC was discussed by using Raman and XRD results. The BET surface area of Cu/HMPC was determined to be 620.8 m2 g-1. The Cu/HMPC actively transformed a wide range of amines to imines under very mild reaction conditions. The catalyst Cu/HMPC gave products in excellent yields (98-61%) with very high TON/TOF values (1512/339-833/35 h-1). To the best of our knowledge, this is the most efficient Cu-based heterogeneous eco-catalyst for the synthesis of imines among those reported to date. The Cu can be recovered from used Cu/HMPC by a simple HCl treatment. Versatility, heterogeneity and reusability of Cu/HMPC were tested. A possible mechanism has been proposed.