6001-87-2

Basic information

• Product Name: 3-CHLOROPROPIONIC ACID METHYL ESTER
• Synonyms: 3-chloro-propanoicacimethylester;3-chloro-propionicacimethylester;Methyl 3-chloropropanoate;methyl3-chloropropanoate;Propionic acid, 3-chloro-, methyl ester;USAF do-7;usafdo-7;3-CHLOROPROPIONIC ACID METHYL ESTER
• CAS NO: 6001-87-2
• Molecular Formula: C₄H₇ClO₂
• Molecular Weight: 122.55
• EINECS: 227-844-4
• Product Categories: API Intermediate
• Mol File: 6001-87-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 153.15°C (rough estimate)
• Flash Point: 40.5 °C
• Appearance: /
• Density: 1.1861
• Vapor Pressure: 1.7E-15mmHg at 25°C
• Refractive Index: 1.4263 (estimate)
• CAS DataBase Reference: 3-CHLOROPROPIONIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROPROPIONIC ACID METHYL ESTER(6001-87-2)
• EPA Substance Registry System: 3-CHLOROPROPIONIC ACID METHYL ESTER(6001-87-2)

Safety Data

• Hazardous Substances Data: 6001-87-2(Hazardous Substances Data)

Usage

General Description

3-Chloropropionic acid methyl ester, also known as methyl 3-chloropropionate, is a chemical compound with the molecular formula C4H7ClO2. It is a colorless liquid with a pungent odor, and it is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. 3-CHLOROPROPIONIC ACID METHYL ESTER is considered to be potentially hazardous, as exposure to it can cause irritation to the skin, eyes, and respiratory system. It is important to handle and store 3-chloropropionic acid methyl ester with care, following proper safety protocols and regulations.

InChI:InChI=1/C24H15BrN2O4/c25-15-7-5-14(6-8-15)20-11-12-22(30-20)23(29)26-16-9-10-19(28)17(13-16)24-27-18-3-1-2-4-21(18)31-24/h1-13,27H,(H,26,29)/b24-17+

Upstream product

• 186581-53-3 diazomethane 
• 107-94-8 chloropropionic acid 
• 67-56-1 methanol 
• 57-57-8 β-Propiolactone 
• 814-68-6 acryloyl chloride 
• 554-12-1 propanoic acid methyl ester 
• 7782-50-5 chlorine 
• 292638-85-8 acrylic acid methyl ester 
• 5891-21-4 5-chloro-2-pentanone 
• 108-24-7 acetic anhydride 
• 625-36-5 2-chloropropionyl chloride 
• 64-17-5 ethanol 
• 79-11-8 chloroacetic acid 
• 62886-12-8 allyl β-chloropropionate 

Downstream Products

• 107-31-3 Methyl formate 
• 6149-41-3 methyl ester (3-hydroxy) propionic acid 
• 13984-53-7 methyl 4-acetyl-5-oxohexanoate 
• 292638-85-8 acrylic acid methyl ester 
• 1985-88-2 4-chloro-2-methyl-2-butanol 
• 3852-09-3 methyl 3-methoxypropionate 
• 13532-18-8 methyl 3-(methylthio)propionate 
• 593-81-7 trimethylamine hydrochloride 
• 16332-33-5 (2-methoxycarbonylethyl)trimethylammonium chloride 
• 627-30-5 1-chloro-3-hydroxypropane 
• 19821-28-4 2--glutarsaeure-dimethylester 
• 500292-01-3 Methyl-3-[4-(3-chlorophenyl)piperazin-1-yl]propanoate 
• 1415388-68-9 methyl 5-(2-bromophenyl)-5-cyano-2-oxocyclohexanecarboxylate 
• 33611-43-7 methyl 3-morpholinopropionate 

Relevant articles and documents

Visible Light-Induced Oxidative Chlorination of Alkyl sp3 C-H Bonds with NaCl/Oxone at Room Temperature

A visible light-induced monochlorination of cyclohexane with sodium chloride (5:1) has been successfully accomplished to afford chlorocyclohexane in excellent yield by using Oxone as the oxidant in H2O/CF3CH2OH at room temperature. Other secondary and primary alkyl sp3 C-H bonds of cycloalkanes and functional branch/linear alkanes can also be chlorinated, respectively, under similar conditions. The selection of a suitable organic solvent is crucial in these efficient radical chlorinations of alkanes in two-phase solutions. It is studied further by the achievement of high chemoselectivity in the chlorination of the benzyl sp3 C-H bond or the aryl sp2 C-H bond of toluene.

SUBSTITUTED TRIAZOLOPYRIDINES

Disclosed herein are substituted triazolopyridine serotonin reuptake modulators and/or 5-HT receptor modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

HYDROCHLORINATION OF VINYL AND ALLYL ACRYLATES AND TRANS-CROTONATES

Different orders of addition were established for the addition of hydrogen chloride to vinyl and allyl acrylates and trans-crotonates.The hydrochlorination of vinyl and allyl acrylates takes place regioselectively at the double bond of the acrylic system.The hydrochlorination of vinyl and allyl trans-crotonates takes place at the double bond of the alkenoxy group.Vinyl β-chloropropionate and β-chlorobutyrate were also obtained by transvinylation of the acids with vinyl acetate.The ability of the obtained chloroesters to undergo certain chemical transformations was demonstrated.