336185-22-9

Upstream product

• 501-53-1 benzyl chloroformate 
• 92511-32-5 3-exo-aminobicyclo[2.2.1]hept-5-ene-2-exo-carboxylic acid 
• 1071519-98-6 methyl 3-{[(benzyloxy)carbonyl]amino}bicyclo[2.2.1]hept-5-ene-2-carboxylate 
• 96243-73-1 (1R,2S,3R,4S)-3-(methoxycarbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 
• 17812-27-0 cis-5-norbornene-endo-2,3-dicarboxylic anhydride 

Relevant academic research and scientific papers

NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS

Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.

Stereochemical Studies. Part 103. Saturated Heterocycles. Part 107. Preparation of 3-Mono and 2,3-Di-substituted Pyrimidin-4(3H)-ones in Retro-Diels-Alder Reactions. The Correct 1,2-Disubstituted Structure of the Compounds previously described as 2,3-Disu

The orthofomate cyclization of carboxamides (4) obtained from 3-exo-aminobicyclohept-5-ene-2-exo-carboxylic acid (1) yielded intermediate 8,9,10-trinorbornene-fused pyrimidinones (5) and hence 3-substituted pyrimidin-4(3H)-ones (6) through the spli