33619-58-8Relevant academic research and scientific papers
Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization
Dhiman, Shiv,Saini, Hitesh Kumar,Nandwana, Nitesh Kumar,Kumar, Dalip,Kumar, Anil
, p. 23987 - 23994 (2016)
A novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.
