RSC Advances p. 23987 - 23994 (2016)
Update date:2022-07-30
Topics:
Dhiman, Shiv
Saini, Hitesh Kumar
Nandwana, Nitesh Kumar
Kumar, Dalip
Kumar, Anil
A novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.
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