336192-71-3

Upstream product

• 459-46-1 4-Fluorobenzyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 336192-66-6 2-tert-butoxycarbonylamino-2-(4-fluoro-benzyl)-4-oxo-butyric acid methyl ester 

Downstream Products

• 336192-76-8 [4-(4-fluoro-benzyl)-3-oxo-hexahydro-pyridazin-4-yl]-carbamic acid tert-butyl ester 
• 336192-85-9 7-tert-butoxycarbonylamino-7-(4-fluoro-benzyl)-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

The synthesis of β-strand mimetic templates via regioselective 1,3-dipolar cycloaddition with vinylsulfone

We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include potent and selective inhibitors of serine proteases.