336192-85-9Relevant academic research and scientific papers
The synthesis of β-strand mimetic templates via regioselective 1,3-dipolar cycloaddition with vinylsulfone
Fuchi, Nobuhiro,Doi, Takayuki,Harada, Takeo,Urban, Jan,Cao, Bolong,Kahn, Michael,Takahashi, Takashi
, p. 1305 - 1308 (2007/10/03)
We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include potent and selective inhibitors of serine proteases.
