33630-20-5

Basic information

• Product Name: 4-METHOXY-2-PHENYLPYRIMIDINE
• Synonyms: SPECS AC-907/25005123;4-METHOXY-2-PHENYLPYRIMIDINE;Pyrimidine, 4-methoxy-2-phenyl-
• CAS NO: 33630-20-5
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 33630-20-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 223.8 °C at 760 mmHg
• Flash Point: 81.3 °C
• Appearance: /
• Density: 1.127 g/cm³
• Vapor Pressure: 0.141mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 4-METHOXY-2-PHENYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-2-PHENYLPYRIMIDINE(33630-20-5)
• EPA Substance Registry System: 4-METHOXY-2-PHENYLPYRIMIDINE(33630-20-5)

Safety Data

• Hazardous Substances Data: 33630-20-5(Hazardous Substances Data)

Usage

General Description

4-Methoxy-2-phenylpyrimidine is a chemical compound with the molecular formula C11H10N2O. It is a pyrimidine derivative with a methoxy group and a phenyl group attached to the pyrimidine ring. 4-METHOXY-2-PHENYLPYRIMIDINE is often used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It has also been studied for its potential biological activities, including its use as a building block for the development of new drugs. Additionally, 4-methoxy-2-phenylpyrimidine has been investigated for its role in various chemical reactions and as a starting material in organic synthesis.

InChI:InChI=1/C11H10N2O/c1-14-10-7-8-12-11(13-10)9-5-3-2-4-6-9/h2-8H,1H3

Upstream product

• 108-86-1 bromobenzene 
• 262353-35-5 2-iodo-4-methoxypyrimidine 
• 22536-63-6 2-chloro-4-methoxypyrimidine 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 

Downstream Products

• 33643-94-6 4-oxo-2-phenyl-3,4-dihydropyrimidine 
• 1217887-56-3 C₁₂H₉F₃N₂O 
• 14790-42-2 4-chloro-2-phenylpyrimidine 

Relevant articles and documents

Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes

Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.

Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines

We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrimidines.