33630-20-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-2-phenylpyrimidine is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activities. It serves as a building block for the development of new drugs, contributing to the creation of various medicinal compounds.
Used in Organic Synthesis:
In the field of organic synthesis, 4-methoxy-2-phenylpyrimidine is utilized as a starting material. Its unique structure allows it to participate in various chemical reactions, facilitating the production of a range of organic compounds.
Used in Chemical Research:
4-Methoxy-2-phenylpyrimidine has been investigated for its role in chemical reactions, providing insights into reaction mechanisms and the development of novel synthetic pathways. This research contributes to the advancement of chemical science and technology.

InChI:InChI=1/C11H10N2O/c1-14-10-7-8-12-11(13-10)9-5-3-2-4-6-9/h2-8H,1H3

Upstream product

• 591-50-4 iodobenzene 
• 262353-35-5 2-iodo-4-methoxypyrimidine 
• 108-86-1 bromobenzene 
• 22536-63-6 2-chloro-4-methoxypyrimidine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1217887-56-3 C₁₂H₉F₃N₂O 
• 33643-94-6 4-oxo-2-phenyl-3,4-dihydropyrimidine 
• 14790-42-2 4-chloro-2-phenylpyrimidine 

Relevant academic research and scientific papers

Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes

Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.

Pd(II)-Catalyzed ortho-trifluoromethylation of arenes using TFA as a promoter

"Chemical equation presented" A Pd(II)-catalyzed C-H activation/trifluoromethylation of arenes with an electrophilic trifluoromethylation reagent using diverse heterocycle directing groups is reported. The presence of trifluoroacetic acid is crucial for this catalytic reaction.

Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines

We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrimidines.

Synthesis of new polyaza heterocycles. Part 42: Diazines

Using Pd-catalyzed Stille cross-coupling reactions, we report here the synthesis of various mono- or bis(tri-n-butylstannyl)diazines which were reacted with various halogenated diazines to access to various polyaza heterocyclic derivatives.