33643-94-6

Basic information

• Product Name: 4-HYDROXY-2-PHENYLPYRIMIDINE
• Synonyms: 4-HYDROXY-2-PHENYLPYRIMIDINE;4(1H)-Pyrimidinone, 2-phenyl-;2-PHENYL-3,4-DIHYDROPYRIMIDIN-4-ONE
• CAS NO: 33643-94-6
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Mol File: 33643-94-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 204-206 °C(Solv: water (7732-18-5))
• Appearance: /
• Density: 1.2 g/cm³
• Refractive Index: 1.623
• Storage Temp.: 2-8°C
• PKA: 8.44±0.40(Predicted)
• CAS DataBase Reference: 4-HYDROXY-2-PHENYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-2-PHENYLPYRIMIDINE(33643-94-6)
• EPA Substance Registry System: 4-HYDROXY-2-PHENYLPYRIMIDINE(33643-94-6)

Safety Data

• Hazardous Substances Data: 33643-94-6(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-2-phenylpyrimidine is a chemical compound, classified under pyrimidines & derivatives. This chemical is colorless to light yellow liquid in physical appearance. The molecular formula of 4-Hydroxy-2-phenylpyrimidine is C10H8N2O. 4-HYDROXY-2-PHENYLPYRIMIDINE is used primarily in the field of organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. There is limited information regarding its toxicity and dangers to human health. Like many chemicals, it needs to be handled carefully, and its exposure should be limited. This chemical is not classified as hazardous under GHS (Globally Harmonized System) classifications, however, its specific effects on human health and its environmental impact have not been thoroughly researched.

InChI:InChI=1/C10H8N2O/c13-9-6-7-11-10(12-9)8-4-2-1-3-5-8/h1-7H,(H,11,12,13)

Upstream product

• 33630-20-5 2-phenyl-4-methoxypyrimidine 
• 618-39-3 benzamidin 
• 623-47-2 propynoic acid ethyl ester 
• 15934-46-0 benzamidene hydrochloride 
• 5751-20-2 2-Methylthiouracil 
• 960-16-7 tributylphenylstannane 
• 141-90-2 2-thiouracil 
• 59938-07-7 (3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one 
• 1670-14-0 benzamidine monohydrochloride 
• 151227-74-6 1-oxido-1-phenyl-4-cyano-4-triphenylphosphonio-2-aza-1,3-butadiene 
• 98-88-4 benzoyl chloride 
• 14735-70-7 diexo-3-Aza-4-oxotricyclo<4.2.1.0^2,5>non-7-ene 
• 825-60-5 benzimidic acid ethyl ester 

Downstream Products

• 14790-42-2 4-chloro-2-phenylpyrimidine 
• 1266476-82-7 N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-ethynyl-2-phenyl-pyrimidin-4-amine 
• 1266479-98-4 4,5-dibromo-2-phenylpyrimidine 
• 1266480-05-0 N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-amine 
• 1266480-03-8 tert-butyl 5-cyclopropyl-3-(5-iodo-2-phenylpyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate 
• 1266477-07-9 (E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine 
• 26786-28-7 5-bromo-4-hydroxy-2-phenylpyrimidine 
• 1266480-00-5 5-iodo-2-phenylpyrimidin-4-ol 
• 1266480-01-6 4-bromo-5-iodo-2-phenylpyrimidine 
• 1266480-02-7 N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine 
• 1266480-04-9 tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate 
• 1266476-75-8 5-bromo-N-(5-cyclopropyl-2H-pyrazol-3-yl)-2-phenyl-pyrimidin-4-amine 
• 26786-28-7 5-bromo-2-phenyl-3H-pyrimidin-4-one 

Relevant articles and documents

Discovery of wtRET and V804MRET Inhibitors: From Hit to Lead

Oncogenic activation of RET kinase has been found in several neoplastic diseases, like medullary thyroid carcinoma, multiple endocrine neoplasia, papillary thyroid carcinoma, and non-small-cell lung cancer. Currently approved RET inhibitors were not originally designed to be RET inhibitors, and their potency against RET kinase has not been optimized. Hence, novel compounds able to inhibit both wild-type RET (wtRET) and its mutants (e.g., V804MRET) are needed. Herein we present the development and the preliminary evaluation of a new sub-micromolar wtRET/V804MRET inhibitor, N-(2-fluoro-5-trifluoromethylphenyl)-N′-{4′-[(2′′-benzamido)pyridin-4′′-ylamino]phenyl}urea (69), endowed with a 4-anilinopyridine structure, starting from our previously identified 4-anilinopyrimidine hit compound. Profiling against a panel of kinases indicated 69 as a multi cKIT/wtRET/V804MRET inhibitor.

PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS

The present invention relates to compounds II useful as inhibitors of treating tuberculosis. The invention also provides processes for preparing compounds of the invention.

A convenient synthesis of 5- and 6-substituted 2-phenyl-3H-pyrimidin-4-ones

A simple and convenient one-pot procedure for the synthesis of 5- and 6-substituted 2-phenyl-3H-pyrimidin-4-ones by the condensation of 4-alkoxy-1,1,1-trichloroalk-3-en-2-ones with benzamidine hydrochloride is described. Georg Thieme Verlag Stuttgart.