33659-45-9

Usage

Uses

Used in Pharmaceutical Industry:
Chloro(triisopropylphosphine)gold,97% is used as a catalyst for the synthesis of complex organic molecules, which are essential in the production of pharmaceuticals. Its high purity ensures the quality and efficiency of the reactions involved in drug manufacturing.
Used in Fine Chemicals Industry:
In the fine chemicals industry, Chloro(triisopropylphosphine)gold,97% is utilized as a catalyst for the synthesis of high-value organic compounds. Its high purity and catalytic properties contribute to the production of specialty chemicals with specific applications.
Used in Material Science:
Chloro(triisopropylphosphine)gold,97% is employed in the development of new materials, where its catalytic properties aid in the synthesis of advanced materials with unique properties. This contributes to the advancement of material science and the creation of innovative products.
Used in Research and Development:
In research and development, Chloro(triisopropylphosphine)gold,97% is used as a catalyst in the study of gold-catalyzed reactions. Its high purity and catalytic properties enable scientists to explore new reaction pathways and develop novel synthetic methods, furthering the understanding of organogold chemistry.
Overall, Chloro(triisopropylphosphine)gold,97% is a versatile organogold compound with a wide range of applications across various industries, including pharmaceuticals, fine chemicals, material science, and research and development. Its high purity and catalytic properties make it an essential tool in the synthesis of complex organic molecules and the advancement of chemical and material sciences.

Upstream product

• 6476-36-4 tris(1-methylethyl)phosphine 
• 39929-21-0 (tetrahydrothiophene)gold(I) chloride 
• 29892-37-3 chloro(dimethylsulfide) gold(I) 
• 21050-13-5 bis(triphenylphosphine)iminium chloride 

Downstream Products

• 118473-92-0 {IrAu₂H₃(P(i-Pr)3)2(triphos)}{CF₃SO₃}2 
• 118474-18-3 {IrAuH₃(P(i-Pr)3)(triphos)}{CF₃SO₃} 
• 23743-05-7 BH₂Cl(P(C₆H₅)3) 
• 254884-84-9 C₆H₅P(S)(SAu(P(CH(CH₃)2)3))2 
• 778583-10-1 [AuFe2Cp2(μ-PPh2)(CO)2(P(i)Pr3)] 
• 1204474-60-1 [AuMo2(cyclopentadienyl)2(μ-PCy2)(CO)2(P(i)Pr3)] 
• 197569-97-4 (benzophenoneimine)(triisopropylphosphane)gold(I) tetrafluoroborate 

Relevant academic research and scientific papers

Neutral R3PAuGe9(Hyp)3 (R=Et, nPr, iPr, nBu, tBu, Cy) (Hyp=Si(SiMe3) Clusters give new insights into the ligand strength of the metalloid [Ge9(Hyp)3]? cluster

We present new insights into the ligand strength of the metalloid [Ge9(Hyp)3]? cluster (Hyp=Si(SiMe3)3) alongside novel neutral Ge9 clusters of the composition R3PAuGe9(Hyp)3 (R=Et, nPr, iPr, nBu, tBu, Cy). These clusters are synthesized in good yields from KGe9(Hyp)3 and R3PAuCl. Further experiments with these new clusters show that the ligand strength of [Ge9(Hyp)3]? is in between aryl and alkyl phosphines.

Gold(I) Phosphine Derivatives with Improved Selectivity as Topically Active Drug Leads to Overcome 5-Nitroheterocyclic Drug Resistance in Trichomonas vaginalis

Trichomonas vaginalis causes the most common, nonviral sexually transmitted infection. Only metronidazole (Mz) and tinidazole are approved for treating trichomoniasis, yet resistance is a clinical problem. The gold(I) complex, auranofin, is active against T. vaginalis and other protozoa but has significant human toxicity. In a systematic structure-activity exploration, we show here that diversification of gold(I) complexes, particularly as halides with simple C1-C3 trialkyl phosphines or as bistrialkyl phosphine complexes, can markedly improve potency against T. vaginalis and selectivity over human cells compared to that of the existing antirheumatic gold(I) drugs. All gold(I) complexes inhibited the two most abundant isoforms of the presumed target enzyme, thioredoxin reductase, but a subset of compounds were markedly more active against live T. vaginalis than the enzyme, suggesting that alternative targets exist. Furthermore, all tested gold(I) complexes acted independently of Mz and were able to overcome Mz resistance, making them candidates for the treatment of Mz-refractory trichomoniasis.

Diphenylphosphide-bridged diiron derivatives of [Fe 2(η5-C5H5)2(μ-H) (μ-PPh2)(CO)2]

The complex trans-[Fe2Cp2(μ-H)(μ-PPh 2)(CO)2] is obtained in 91% yield by refluxing toluene solutions of [Fe2Cp2(CO)4] (Cp = μ5-C5H5) and the secondary phosphine PPh2H. This compound isomerizes upon irradiation with visible - UV light under a CO atmosphere to yield cis-[Fe2Cp2(μ-H) (μ-PPh2)(CO)2]. The above hydride complexes react under photochemical conditions with 1 equiv of secondary phosphines PR2H (R = Et, Ph) to give the corresponding monocarbonyl compounds [Fe 2Cp2(μ-PPh2)(μ-PR2)(μ-CO)] via the hydride intermediates [Fe2Cp2(μ-H)(μ- PPh2)(CO)(PR2H)] (detected and isolated for R = Et). Deprotonation of trans[Fe2Cp2(μ-H)(μ-PPh 2)(CO)2] with LiBu gives the binuclear anion [Fe 2Cp2(μ-PPh2)(CO)2]. This highly nucleophilic carbonylate reacts rapidly with [AuCl(PiPr3)] or MeI to give the corresponding gold diiron cluster [AuFe2Cp 2(μ-PPh2)(CO)2(PiPr3)] or methyl derivative [Fe2Cp2(Me)(μ-PPh 2)(μ-CO)(CO)2], respectively. Both hydrides cis- and trans- [Fe2Cp2(μ-H)(μPPh2)(CO) 2] can be reversibly oxidized at low temperature to the corresponding cation radicals cis- and trans- [Fe2Cp2(μ-H)(H- PPh2)(CO)2]-. At room temperature, however, the trans dicarbonyl cation isomerizes to its cis isomer, which in turn experiences a degradation process involving the reductive elimination of the bridging groups. The structures of the new complexes are analyzed on the basis of the corresponding IR and NMR (1H, 31P and 13C) spectroscopic data. The nature of the new radical cations is analyzed also on the basis of cyclic voltammetry and ESR measurements.

Ruthenium tri- and digold hydride clusters

The synthesis and characterization of ruthenium-gold clusters, of composition [(triars)RuH3{Au(L)}3][PF6]2 (triars = CH3C(CH2AsPh2)3; L = PPh3, PEt3 P-i-Pr3) and [(triphos)RuH3{Au(L)}3][PF6]2 (triphos = CH3C(CH2PPh2)3; L = PPh3 P-i-Pr3, AsPh3, As-i-Pr3), type C, is reported. They were obtained by reacting the gold cations {Au(L)}+ (3 equiv) with either [RuH4(triars)] or [RuH(BH4)(triphos)] (1 equiv). The X-ray crystal structure of [(triphos)RuH3{Au(PPh3)}3][PF6] 2 shows the presence of a RuAu3 tetrahedron with the ruthenium atom capped by triphos, while each gold atom is coordinated to one PPh3. The hydride ligands, which could be located, occupy bridging positions above each of the Ru-Au2 faces but are displaced toward one RuAu edge. Crystal data: space group R3c a = 20.150(3) ?, c = 45.229(9) ?, Z = 6, V = 15904(9) ?3, ρ(calcd) = 1.501 g cm-3, and R = 0.051. The addition of the gold cations {Au(L)}+ (2 equiv) to either [RuH4(triars)] or [RuH(BH4)(triphos)] (1 equiv), in the presence of a base, gave the trinuclear species [(triars)RuH3{Au(L)}2][PF6] (L = PPh3, P-o-Tol3, P-i-Pr3, AsPh3) and [(triphos)RuH3{Au(L)}2][PF6] (L = PPh3, P-o-Tol3, P-i-Pr3, AsPh3), respectively, type B. These complexes are highly fluxional in solution and have been assigned static structures based on a RuHAu2 tetrahedron, the ruthenium atom being capped by the tripod ligand and each gold being coordinated to a ligand L, while the other two H-atoms are assumed to bridge the Ru-Au edges. Some highly fluxional binuclear compounds of composition [(triars)RuH3{Au(L)}] (L = PPh3, P-o-Tol3) and [(triphos)RuH3{Au(P-o-Tol3)}], type A, could also be characterized in solution.

Preparation and Structure of Hexakismethanium(2+) Salts (2+)(X(1-))2 with L = Et3P, iPr3P and X = BF4(1-), B3O3F4(1-)

Hexaaurated carbon complexes of the type (BF4)2, R = Et (2a), iPr (2b) have been prepared by the reaction of the appropriate (phosphane)gold(I) chlorides R3PAuCl (1a and 1b) with tetrakis(dimethoxyboryl)methane, (13)C-enriched at the central carbon atom, in the presence of excess of CsF in HMPT at room temperature.The products 2a and 2b are characterized by standard spectroscopic methods including direct detection of the interstitial C atoms by (13)C-NMR spectroscopy.The crystal structure of the compound (B3O3F4)2*3CH2Cl2 (3), obtained from partial (anion) hydrolysis has been determined.It contains dications with a central carbon atom surrounded by six (phosphane)gold(I) units.The edges of the CAu6 octahedron represent short Au-Au contacts (aprox. 3.0 Angstroem), which strongly contribute to the formation and stability of these hypercoordinated species.Attempts to prepare a corresponding hexaauriomethanium dication starting from tBu3PAuCl (1c) failed owing to the bulkiness of the (tri-tert-butylphosphane)gold(I) unit.The X-ray structure analysis for 1c verifies an extremly crowded environment of the gold atom with small Au-P-C-angles of only 107 deg leading to efficient shielding of the metal atom by methyl groups. Key Words: Auriophilicity / Gold(I), phosphane complexes / Methanium, hexaaurio(I) compounds

Phosphinegold (I) salts having antiarthritic activity

The compounds are (pyridine) (trisubstituted phosphine) gold(I) salts which have antiarthritic activity.