33661-99-3Relevant academic research and scientific papers
Regio- and Diastereoselective Rhodium-Catalyzed Allylic Substitution with Unstabilized Benzyl Nucleophiles
Pal, Debasis,Wright, Timothy B.,O'Connor, Ryan,Evans, P. Andrew
supporting information, p. 2987 - 2992 (2020/12/09)
We have developed a highly regio- and diastereoselective rhodium-catalyzed allylic substitution of challenging alkyl-substituted secondary allylic carbonates with benzylzinc reagents, which are prepared from widely available benzyl halides. This process utilizes rhodium(III) chloride as a commercially available, high-oxidation state and bench-stable pre-catalyst to provide a rare example of a regio- and diastereoselective allylic substitution in the absence of an exogenous ligand. This reaction tolerates electronically diverse benzylzinc nucleophiles and an array of functionalized and/or challenging aliphatic allylic electrophiles. Finally, the configurational fluxionality of the rhodium-allyl intermediate is exploited to develop a novel diastereoselective process for the construction of vicinal acyclic ternary/ternary stereogenic centers, in addition to a cyclic ternary/quaternary derivative.
P-menthan-3-ol alkylated derivatives and their use as refreshing agents
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Page/Page column 3, (2009/07/10)
The invention concerns a 3-alkylated crystallized (1R,4S)-p-menthan-(3)-ol derivative, of formula A or B, wherein: either when R represents hydrogen or a methyl radical, R represents a —(CH2)n-OH where n can be 1, 2 and 3, or when R represents a
