336625-00-4Relevant academic research and scientific papers
An improved approach to trifluoromethyl substituted Morita-Baylis-Hillman adduct: Fluorinated dehydro-β-amino acids
Sergeeva, Natalia N.,Golubev, Alexander S.,Hennig, Lothar,Findeisen, Matthias,Paetzold, Eckhard,Oehme, Günther,Burger, Klaus
, p. 41 - 44 (2001)
The [α-(alkoxycarbonyl)vinyl]diisobutylaluminium reagents generated by hydroalumination from α,β-acetylenic esters and DIBAL-H were reacted with N-acylimines of hexafluoroacetone and methyl trifluoropyruvate to give trifluoromethyl substituted dehydro-β-a
Synthesis of partially fluorinated β-amino acids via Morita-Baylis-Hillman reaction
Sergeeva,Golubev,Burger
, p. 281 - 285 (2007/10/03)
A convenient synthesis of fluorinated β-amino acids via Morita-Baylis-Hillman reaction is described. Hydrogenation of Morita-Baylis-Hillman adducts or cuprate addition to the double bond provides ready access to α-substituted β,β-bis(trifluoromethyl) β-am
