336628-65-0Relevant articles and documents
Silylaryl Halides Can Replace Triflates as Aryne Precursors
Mesgar, Milad,Daugulis, Olafs
, p. 3910 - 3913 (2016)
Silylaryl bromides and iodides can be prepared in one step from commercially available starting materials. Arynes can be generated from these compounds under conditions nearly identical to those employed for silylaryl triflates. Three distinct transformat
Synthesis of obscuraminol A using an organocatalyzed enantioselective Henry reaction
Filippova, Liudmila,Antonsen, Simen,Stenstr?m, Yngve,Hansen, Trond Vidar
supporting information, p. 6572 - 6577 (2016/09/23)
The first synthesis of the polyunsaturated amino alcohol natural product obscuraminol A is reported. This stereoselective synthesis was based on an anti- and enantioselective organocatalyzed Henry reaction followed by a chemoselective SmI2-mediated reduction that affected only the nitro-group of the Henry product. These efforts yielded obscuraminol A where the configuration of the all-Z skipped double bonds was conserved from the starting material, i.e. the ethyl ester of (all-Z)-eicosa-5,8,11,14,17-pentaenoic acid. Our synthesis confirmed the reported structure of obscuraminol A.
Highly enantioselective henry reactions in water catalyzed by a copper tertiary amine complex and applied in the synthesis of (S)-N-trans-feruloyl octopamine
Lai, Guoyin,Guo, Fengfeng,Zheng, Yueqin,Fang, Yang,Song, Haigang,Xu, Kun,Wang, Sujing,Zha, Zhenggen,Wang, Zhiyong
supporting information; scheme or table, p. 1114 - 1117 (2011/03/21)
It's in the water! A new copper tertiary amine complex was prepared and applied in asymmetric Henry reactions in water and in the short synthesis of (S)-N-trans-feruloyl octopamine. This catalytic system provided an approach to the enantioselective Henry reaction of aldehydes with hydroxyl substituents (see graphic).
