33667-80-0

Basic information

• Product Name: 2,4,6-TRIMETHYL DIPHENYL SULFIDE
• Synonyms: 2,4,6-TRIMETHYL DIPHENYL SULFIDE;Trimethyldiphenylsulfide;2,4,6-Trimethyl;2,4,6-TRIMETHYL DIPHENYL SULFIDE 97%MIN;mesityl(phenyl)sulfane;2,4,6-TRIMETHYL DIPH
• CAS NO: 33667-80-0
• Molecular Formula: C₁₅H₁₆S
• Molecular Weight: 228.35
• Mol File: 33667-80-0.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 305.698 °C at 760 mmHg
• Flash Point: 128.935 °C
• Appearance: /
• Density: 1.075 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2,4,6-TRIMETHYL DIPHENYL SULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIMETHYL DIPHENYL SULFIDE(33667-80-0)
• EPA Substance Registry System: 2,4,6-TRIMETHYL DIPHENYL SULFIDE(33667-80-0)

Safety Data

• Hazardous Substances Data: 33667-80-0(Hazardous Substances Data)

Usage

General Description

2,4,6-Trimethyl diphenyl sulfide is a chemical compound that belongs to the family of sulfides. It is a clear, colorless liquid with a strong odor and is commonly used as a solvent and as an intermediate in the production of various organic compounds. This chemical is also known for its ability to act as a reducing agent in organic synthesis. Additionally, it has potential applications in the pharmaceutical and agrochemical industries. However, 2,4,6-trimethyl diphenyl sulfide may pose health risks if not handled properly, as it is toxic and can cause skin and eye irritation. It is important to follow proper safety precautions when working with this chemical.

InChI:InChI=1/C15H16S/c1-11-9-12(2)15(13(3)10-11)16-14-7-5-4-6-8-14/h4-10H,1-3H3

Upstream product

• 1541-10-2 mesitylthiol 
• 42157-57-3 2-(ethylsulfanyl)-1,3,5-trimethylbenzene 
• 118-92-3 anthranilic acid 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 108-98-5 thiophenol 
• 882-33-7 diphenyldisulfane 
• 108-67-8 1,3,5-trimethyl-benzene 
• 1483-92-7 bis(2,4,6-trimethylphenyl)disulfide 
• 603-33-8 triphenylbismuthane 
• 59344-64-8 tris(2,4,6-trimethylphenyl)bismuth 
• 5980-97-2 mesitylboronic acid 
• 931-59-9 benzenesulfenyl chloride 
• 873-55-2 sodium benzenesulfonate 
• 4028-63-1 iodomesitylene 

Downstream Products

• 3112-82-1 (2,4,6-trimethylphenyl) phenyl sulfone 

Relevant articles and documents

Safe, Scalable, Inexpensive, and Mild Nickel-Catalyzed Migita-Like C?S Cross-Couplings in Recyclable Water

A new approach to C?S couplings is reported that relies on nickel catalysis under mild conditions, enabled by micellar catalysis in recyclable water as the reaction medium. The protocol tolerates a wide range of heteroaromatic halides and thiols, including alkyl and heteroaryl thiols, leading to a variety of thioethers in good isolated yields. The method is scalable, results in low residual metal in the products, and is applicable to syntheses of targets in the pharmaceutical area. The procedure also features an associated low E Factor, suggesting a far more attractive entry than is otherwise currently available, especially those based on unsustainable loadings of Pd catalysts.

A Robust Pd-Catalyzed C-S Cross-Coupling Process Enabled by Ball-Milling

An operationally simple mechanochemical C-S coupling of aryl halides with thiols has been developed. The reaction process operates under benchtop conditions without the requirement for a (dry) solvent, an inert atmosphere, or catalyst preactivation. The reaction is finished within 3 h. The reaction is demonstrated across a broad range of substrates; the inclusion of zinc metal has been found to be critical in some instances, especially for coupling of alkyl thiols.

Copper-Catalyzed Electrophilic Thiolation of Organozinc Halides by Using N-Thiophthalimides Leading to Polyfunctional Thioethers

(Hetero)aryl, benzylic, and alkyl zinc halides were thiolated with N-thiophthalimides at 25 °C within 1 h in the presence of 5–10 % Cu(OAc)2?H2O to furnish the corresponding polyfunctionalized thioethers in good yields. This electrop