336784-86-2

Upstream product

• 336784-85-1 4-hydroxy-4-[3-methoxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-1-(tetrahydro-pyran-2-yloxy)-butan-2-one 
• 121-33-5 vanillin 
• 91471-08-8 3-methoxy-4-(tetrahydropyran-2-yloxy)benzaldehyde 

Downstream Products

• 377047-76-2 (E)-3-(3,4-Diacetoxy-phenyl)-acrylic acid (E)-4-(4-hydroxy-3-methoxy-phenyl)-2-oxo-but-3-enyl ester 
• 377047-67-1 (E)-3-(4-Acetoxy-phenyl)-acrylic acid (E)-4-(4-hydroxy-3-methoxy-phenyl)-2-oxo-but-3-enyl ester 
• 336784-87-3 C₁₄H₂₀O₄Si 
• 377047-74-0 (E)-3-(3-Acetoxy-phenyl)-acrylic acid (E)-4-(4-hydroxy-3-methoxy-phenyl)-2-oxo-but-3-enyl ester 

Relevant academic research and scientific papers

Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease

The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric, gingko biloba, and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.

Total synthesis of calebin-A, preparation of its analogues, and their neuronal cell protectivity against β-amyloid insult

A total synthesis of Calebin-A (1), a novel curcuminoid isolated from turmeric (Curcuma longa, Zingiberaceae) that has been demonstrated to protect neuronal cells from β-amyloid insult, was successfully achieved in four steps. Elaborating on this synthetic route, 13 analogues were prepared for a structure-activity relationship (SAR) study. It was found that the parent compound 1 and derivatives 21, 28, and 30 protect PC12 rat pheocromocytoma and IMR-32 human neuroblastoma cells from β-amyloid(25-35) insult. These results suggest that hydroxy group at para-position is most critical for the expression of biological activity.