377047-76-2

Upstream product

• 336784-85-1 4-hydroxy-4-[3-methoxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-1-(tetrahydro-pyran-2-yloxy)-butan-2-one 
• 121-33-5 vanillin 
• 91471-08-8 3-methoxy-4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 88623-81-8 3,4-diacetoxycinnamic acid 
• 336784-86-2 (E)-1-Hydroxy-4-(4-hydroxy-3-methoxy-phenyl)-but-3-en-2-one 

Relevant academic research and scientific papers

Total synthesis of calebin-A, preparation of its analogues, and their neuronal cell protectivity against β-amyloid insult

A total synthesis of Calebin-A (1), a novel curcuminoid isolated from turmeric (Curcuma longa, Zingiberaceae) that has been demonstrated to protect neuronal cells from β-amyloid insult, was successfully achieved in four steps. Elaborating on this synthetic route, 13 analogues were prepared for a structure-activity relationship (SAR) study. It was found that the parent compound 1 and derivatives 21, 28, and 30 protect PC12 rat pheocromocytoma and IMR-32 human neuroblastoma cells from β-amyloid(25-35) insult. These results suggest that hydroxy group at para-position is most critical for the expression of biological activity.