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3368-13-6

Benzolamide, also known as Benzenesulfonamide or Diacarb, is a carbonic anhydrase inhibitor that functions as a diuretic to manage fluid retention and lower intraocular pressure in glaucoma. It operates by inhibiting the activity of carbonic anhydrase, an enzyme that catalyzes the production of bicarbonate ions and protons. This inhibition leads to a reduction in the reabsorption of sodium and water in the kidneys, resulting in increased urine output and decreased fluid retention. Benzolamide is available in oral tablet form and is generally well-tolerated, although it may cause side effects such as dizziness, fatigue, and an elevated risk of kidney stones.

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  • 3368-13-6 Structure

  • Basic information

    1. Product Name: Benzolamide
    2. Synonyms: Benzolamide;5-(phenylsulfonylamino)-1,3,4-thiadiazole-2-sulfonamide;2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide;1,3,4-Thiadiazole-2-sulfonamide, 5-[(phenylsulfonyl)amino]-
    3. CAS NO:3368-13-6
    4. Molecular Formula: C8H8N4O4S3
    5. Molecular Weight: 292.36
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 3368-13-6.mol

  • Chemical Properties

    1. Melting Point: 239.5°C (rough estimate)
    2. Boiling Point: 585.9°Cat760mmHg
    3. Flash Point: 308.2°C
    4. Appearance: /
    5. Density: 1.6772 (rough estimate)
    6. Vapor Pressure: 1.03E-13mmHg at 25°C
    7. Refractive Index: 1.5690 (estimate)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 4.42±0.40(Predicted)
    11. Water Solubility: 384.4mg/L(25 oC)
    12. CAS DataBase Reference: Benzolamide(CAS DataBase Reference)
    13. NIST Chemistry Reference: Benzolamide(3368-13-6)
    14. EPA Substance Registry System: Benzolamide(3368-13-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3368-13-6(Hazardous Substances Data)

3368-13-6 Usage

Uses

Used in Ophthalmology:
Benzolamide is used as a treatment for glaucoma to reduce intraocular pressure. Its action in inhibiting carbonic anhydrase helps to decrease the production of aqueous humor, thereby lowering the pressure within the eye and reducing the risk of optic nerve damage.
Used in Cardiology:
Benzolamide is used as a diuretic for the management of edema, a condition characterized by an excess of fluid in the body's tissues. By increasing urine production, it helps to alleviate fluid buildup and reduce swelling, particularly in cases of heart failure or other conditions that impair the heart's ability to pump blood effectively.
Used in Pulmonology:
Benzolamide is used as a treatment for high-altitude sickness, a condition that can occur when individuals ascend to high altitudes rapidly and experience a decrease in oxygen levels. The diuretic effect of benzolamide can help to reduce the symptoms of altitude sickness, such as headache, dizziness, and shortness of breath, by promoting fluid excretion and maintaining electrolyte balance.

Check Digit Verification of cas no

The CAS Registry Mumber 3368-13-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,6 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3368-13:
(6*3)+(5*3)+(4*6)+(3*8)+(2*1)+(1*3)=86
86 % 10 = 6
So 3368-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N4O4S3/c9-18(13,14)8-11-10-7(17-8)12-19(15,16)6-4-2-1-3-5-6/h1-5H,(H,10,12)(H2,9,13,14)

3368-13-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(benzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide

1.2 Other means of identification

Product number -
Other names 3dbu

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3368-13-6 SDS

3368-13-6Relevant articles and documents

Synthesis and evaluation of new carbonic anhydrase inhibitors

Xiao, Zhonghai,Duan, Ruifeng,Cui, Wenyu,Zhang, Yanfang,Zhang, Shouguo,Chen, Fangjin,Zhang, Yankun,Liu, Jiaying,Zhang, Dongxiang,Meng, Yuan,Wang, Lin,Wang, Hai

experimental part, p. 3221 - 3228 (2011/06/24)

A series of new sulfamide derivatives have been synthesized, their structures were confirmed by 1H NMR and ESI-MS. Some target compounds were assessed by the tool of Dock6, and inhibition effects of all the new compounds on carbonic anhydrase II have been investigated. In addition, some compounds have been investigated for their antihypoxic effects in mice. Results indicated that nine target compounds exhibit as effectively as acetazolamide and 10 compounds have more potent inhibition effects on carbonic anhydrase II than acetazolamide. Three of them (I-8, I-18 and I′-3) can prolong markedly the survival time of mice in hypoxia, which are worth carrying out further studies.

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