3368-13-6 Usage
General Description
Benzolamide, also known as Benzenesulfonamide or Diacarb, is a carbonic anhydrase inhibitor used as a diuretic to control fluid retention and reduce intraocular pressure in glaucoma. It works by inhibiting the action of carbonic anhydrase, an enzyme responsible for the production of bicarbonate ions and protons. By reducing the production of bicarbonate ions, benzolamide decreases the reabsorption of sodium and water in the kidneys, leading to increased urine production and reduced fluid retention. It is available as an oral tablet and is generally well-tolerated, but may cause side effects such as dizziness, fatigue, and an increased risk of kidney stones. Benzolamide is used as a treatment for conditions such as glaucoma, edema, and high-altitude sickness.
Check Digit Verification of cas no
The CAS Registry Mumber 3368-13-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,6 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3368-13:
(6*3)+(5*3)+(4*6)+(3*8)+(2*1)+(1*3)=86
86 % 10 = 6
So 3368-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N4O4S3/c9-18(13,14)8-11-10-7(17-8)12-19(15,16)6-4-2-1-3-5-6/h1-5H,(H,10,12)(H2,9,13,14)
3368-13-6Relevant articles and documents
Synthesis and evaluation of new carbonic anhydrase inhibitors
Xiao, Zhonghai,Duan, Ruifeng,Cui, Wenyu,Zhang, Yanfang,Zhang, Shouguo,Chen, Fangjin,Zhang, Yankun,Liu, Jiaying,Zhang, Dongxiang,Meng, Yuan,Wang, Lin,Wang, Hai
experimental part, p. 3221 - 3228 (2011/06/24)
A series of new sulfamide derivatives have been synthesized, their structures were confirmed by 1H NMR and ESI-MS. Some target compounds were assessed by the tool of Dock6, and inhibition effects of all the new compounds on carbonic anhydrase II have been investigated. In addition, some compounds have been investigated for their antihypoxic effects in mice. Results indicated that nine target compounds exhibit as effectively as acetazolamide and 10 compounds have more potent inhibition effects on carbonic anhydrase II than acetazolamide. Three of them (I-8, I-18 and I′-3) can prolong markedly the survival time of mice in hypoxia, which are worth carrying out further studies.
