336818-16-7Relevant articles and documents
Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV
Kondo, Takashi,Sugimoto, Isamu,Nekado, Takahiro,Ochi, Kenya,Ohtani, Tazumi,Tajima, Yohei,Yamamoto, Susumu,Kawabata, Kazuhito,Nakai, Hisao,Toda, Masaaki
, p. 2715 - 2735 (2008/02/08)
A series of (4-substituted prolyl)prolinenitriles were synthesized and evaluated as inhibitors of dipeptidylpeptidase IV (DPP-IV). Among those tested, the 4β-[4-(hydroxyphenyl)prolyl]prolinenitriles showed a potent inhibitory activity with a long duration
Synthesis and evaluation of some hydroxyproline-derived peptidomimetics as isoprenyltransferase inhibitors
O'Connell, Celeste E.,Rowell, Cheryl A.,Ackermann, Karen,Garcia, Ana Maria,Lewis, Michael D.,Kowalczyk, James J.
, p. 740 - 742 (2007/10/03)
CA1A2X peptidomimetics containing a modified proline at position A2 were prepared and evaluated for their ability to inhibit farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) in enzymatic and cell- bas