336829-92-6

Usage

Uses

Used in Fragrance Industry:
2,2-dimethylhex-4-yn-1-ol is used as a fragrance ingredient for its slightly sweet and floral scent, contributing to the formulation of perfumes and personal care products.
Used in Chemical Synthesis:
2,2-dimethylhex-4-yn-1-ol serves as a chemical intermediate in the synthesis of other compounds, playing a crucial role in the production of various chemical products.
Safety Note:
Due to its flammable nature, 2,2-dimethylhex-4-yn-1-ol should be handled with caution to prevent accidents or hazards.

Upstream product

• 116252-14-3 ethyl 2,2-dimethylhex-4-ynoate 

Downstream Products

• 1269195-62-1 C₁₂H₂₃N*C₁₅H₂₅NO₄ 

Relevant academic research and scientific papers

Rhodium-catalyzed arylative cyclization for the enantioselective synthesis of (trifluoromethyl)cyclobutanols

A rhodium-catalyzed cyclization of 1-(trifluoro-methyl)-4-alkyn-1-ones with arylboronic acids is described to yield a novel class of small rings: (trifluoromethyl)cyclobutanols bearing an exocyclic double bond. The use of a rhodium/chiral diene complex allowed the reaction to proceed under mild conditions, often with high enantioselectivity. An X-ray crystal structure was obtained confirming the formation of the four-membered ring products.

Synthesis of vaniprevir (MK-7009): Lactamization to prepare a 22-membered macrocycle

Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermolecular palladium-catalyzed cross-couplings, and macrolactamization. Ri