33683-30-6Relevant academic research and scientific papers
Effect of Derivatives of Hydroxamic Acids on Vasculogenic Mimicry
Balaev, A. N.,Khachatryan, D. S.,Khochenkov, D. A.,Khochenkova, Yu. A.,Kolotaev, A. V.,Machkova, Yu. S.,Ohmanovich, K. A.,Osipov, V. N.,Vartanian, A. A.
, p. 252 - 263 (2020)
Abstract—: Vasculogenic mimicry, the formation of vascular channels lined with tumor cells of a highly malignant phenotype, is currently considered as an additional system of blood supply of the tumor. Experimental studies in vivo have repeatedly demonstrated that vascular channels form in the areas of a tumor with a low density of blood vessels. It is supposed that the formation of a network of these channels inside the tumor maintains homeostasis and prevents early necrosis within it. In this work, bifunctional compounds based on a combination of quinazoline and hydroxamic acid in one molecule were examined for the ability to inhibit the migration of tumor cells and vasculogenic mimicry.
PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS
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Page/Page column 17, (2012/03/12)
The invention provides novel compounds based on piperazinylpyrimidine derivatives to be used as protein kinase inhibitors. The compounds may be useful in treating or preventing different cellular proliferation disorders, such as cancer. The present invent
