336877-68-0

Basic information

• Product Name: BOC-4-NITRO-L-PHENYLALANINE
• Synonyms: (S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-NITROPHENYL)PROPANOIC ACID;RARECHEM BK PT 0074;N-TBOC-P-NITRO-L-PHENYLALANINE;N-TERT-BUTOXYCARBONYL-4-NITRO-L-PHENYLALANINE;N-BOC-4-NITRO-L-PHENYLALANINE;N-ALPHA-T-BUTOXYCARBONYL-P-NITRO-L-PHENYLALANINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-4-NITRO-L-PHENYLALANINE;N-ALPHA-T-BUTOXYCARBONYL-(4-NITROPHENYL)-L-ALANINE
• CAS NO: 336877-68-0
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 310.3
• EINECS: 251-450-1
• Mol File: 336877-68-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 490.2°C at 760 mmHg
• Flash Point: 250.2°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 2.01E-10mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: −20°C
• CAS DataBase Reference: BOC-4-NITRO-L-PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-4-NITRO-L-PHENYLALANINE(336877-68-0)
• EPA Substance Registry System: BOC-4-NITRO-L-PHENYLALANINE(336877-68-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 336877-68-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H16N2O6/c1-13(2,3)21-12(18)14-10(11(16)17)8-4-6-9(7-5-8)15(19)20/h4-7,10H,1-3H3,(H,14,18)(H,16,17)/t10-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 336877-66-8 2-amino-2-(4-nitrophenyl)acetic acid 
• 2935-35-5 (S)-2-phenylglycine 

Downstream Products

• 336877-88-4 H-Arg-Phg(4-NO₂)-Leu-Pro-Thr-OH 
• 336877-70-4 L-N-(tert-butoxycarbonyl)-4-(N,N-dimethylamino)phenylglycine 

Relevant articles and documents

New proctolin analogues modified by the novel D-or L-phenylglycine derivatives. Synthesis and biological studies

New analogues of insect neuromodulator proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH), modified in position 2 of the peptide chain by L-or D-phenylglycine and its 4-substituted derivatives were synthesized. For modification of proctolin a series of novel L-or D-phenylglycine derivatives H-Phg(4-NO2)-OH (1), Boc-Phg(4-NO2)-OH (2), Boc-Phg(4-Me2N)-OH (3), H-Phg(4-OBzl)-OH (4), Boc-Phg(4-OBzl)-OH (5), H-D-Phg(4-NO2)-OH (6), Boc-D-Phg(4-NO2,)-OH (7), Boc-D-Phg(4-Me2N)-OH (8), were used. The following proctolin analogues were synthesized: H-Arg-Phg-Leu-Pro-Thr-OH (9), H-Arg-D-Phg-Leu-Pro-Thr-OH (10), H-Arg-Phg(4-OH)-Leu-Pro-Thr-OH (11), H-Arg-D-Phg(4-OH)-Leu-Pro-Thr-OH (12), H-Arg-Phg(4-NO2)-Leu-Pro-Thr-OH (13), H-Arg-D-Phg(4-NO2)-Leu-Pro-Thr-OH (14), H-Arg-Phg(4-NH2)-Leu-Pro-Thr-OH (15), H-Arg-D-Phg(4-NH2)-Leu-Pro-Thr-OH (16), H-Arg-Phg(4-NMe2)-Leu-Pro-Thr-OH (17), H-Arg-D-Phg(4-NMe2)-Leu-Pro-Thr-OH (18). Myotropic activity of proctolin analogues 9-18 was assayed in vitro on the semi-isolated heart of the mealworm Tenebrio molitor and on the foregut of the locust Schistocerca gregaria. All analogues showed a weak or none activity.