336883-67-1Relevant articles and documents
Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir
Masuda, Takeshi,Shibuya, Satoshi,Arai, Masami,Yoshida, Shuku,Tomozawa, Takanori,Ohno, Akiko,Yamashita, Makoto,Honda, Takeshi
, p. 669 - 673 (2003)
We synthesized bicyclic ether sialidase inhibitors such as tetrahydro-furan-2-yl, tetrahydro-pyran-2-yl, and oxepan-2-yl derivatives related to zanamivir. These compounds substituted by diol at the C-3′ and C-4′ positions resulted in the retention of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. Compound 11a in particular showed comparable efficacy in vivo relative to that of oseltamivir phosphate.