33695-57-7

Usage

Uses

Used in Pharmaceutical Industry:
Indan-1-carboxamide is used as a building block in the synthesis of various drugs and biologically active compounds. Its unique structural features and biological activities contribute to the development of new pharmaceuticals.
Used in Agrochemical Production:
Indan-1-carboxamide is used as a precursor in the production of agrochemicals. Its chemical properties make it suitable for the synthesis of various agrochemicals.
Used in Dye Production:
Indan-1-carboxamide is used in the production of dyes. Its chemical structure allows for the creation of different dye compounds.
Used in Organic Compounds Synthesis:
Indan-1-carboxamide is used as a precursor in the synthesis of other organic compounds. Its versatile chemical properties enable its use in various organic synthesis processes.
Used in Medicinal Chemistry and Drug Discovery Research:
Indan-1-carboxamide has potential applications in medicinal chemistry and drug discovery research due to its unique structural features and biological activities. Further studies are needed to fully explore its pharmacological properties and potential therapeutic uses.

InChI:InChI=1/C10H11NO/c11-10(12)9-6-5-7-3-1-2-4-8(7)9/h1-4,9H,5-6H2,(H2,11,12)

Upstream product

• 14381-42-1 Indan-1-carboxylic acid 
• 26452-96-0 methyl indane-1-carboxylate 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 1440968-36-4 N-((perfluorobutyl)sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide 
• 64959-10-0 indan-1-carboxylic acid ethyl ester 
• 29427-69-8 3-oxoindan-1-carboxylic acid 
• 19156-10-6 indan-1-carbonyl chloride 

Downstream Products

• 26452-97-1 1-cyanoindane 
• 54949-92-7 1-aminomethylindan 

Relevant academic research and scientific papers

Amide derivatives and their medical use

The invention relates to novel amide derivatives shown in a structural formula I in the specification or a pharmaceutically acceptable salt thereof, a medicine composition which takes the compounds as active components, and an application of the derivatives or the pharmaceutically acceptable salt of the derivatives to preparation of analgesia medicines. In the structural formula I, R1 and R2 are a hydrogen atom and a C1-C3 alkyl; R3 is hydrogen atom, C1-C3 alkyl, phenyl or a hydroxyl-substituted alkyl.

A practical method for regiocontrolled one-carbon ring contraction

A practical and efficient method for the perfluorobutanesulfonyl azide-mediated one-carbon ring contraction of cyclic enoxysilanes is described. High-yielding procedures for the elaboration of the resulting N-acyl sulfonamide products are reported.

Functional-Group-Directed Diastereoselective Hydrogenation of Aromatic Compounds. 21

Diastereoselective liquid-phase hydrogenation of a series of monosubstituted indan substrates was studied on supported rhodium catalysts. Predominantly the cis-cis diastereomer, obtained by hydrogenation from the diastereoface opposite the substituent at the stereogenic center, and the cis-trans diastereomer, obtained by hydrogenation from the diastereoface on the same side as the substituent, were formed. The diastereoselectivity depends on the balance between steric repulsion and electronic attraction of the substituent with the surface of the catalyst. For alkoxy and carboxyl groups (acid, methyl ester, and amide), the steric repulsion dominated and the cis-cis diastereomer was obtained with moderately high selectivity. The diastereoselectivity obtained in the hydrogenation was influenced by the addition of bases to the reaction mixture. Addition of triethylamine caused a small increase in the selectivity to the cis-cis diastereomer in some substrates, whereas the addition of NaOH significantly increased the selectivity toward the cis-trans isomer in all substrates.