29427-69-8

Basic information

• Product Name: 3-Oxoindane-1-carboxylic acid
• Synonyms: 2,3-dihydro-3-oxo-1h-indene-1-carboxylicacid;3-oxo-2,3-dihydro-1h-indene-1-carboxylicacid;3-OXOINDANE-1-CARBOXYLIC ACID;3-OXO-1-INDAN-1-CARBOXYLIC ACID;3-OXO-1-INDANCARBOXYLIC ACID;3-OXO-INDAN-1-CARBOXYLIC ACID;1-Indanone-3-carboxylic Acid;3-Oxo-1-indan-2-carboxylic acid
• CAS NO: 29427-69-8
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.17
• Product Categories: Benzocycles;pharmacetical;Carboxylic Acids;Miscellaneous;Carboxylic Acids;Fused Ring Systems;Pharmaceutical intermediate;C10;Carbonyl Compounds
• Mol File: 29427-69-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 111-113 °C(lit.)
• Boiling Point: 365.01 °C at 760 mmHg
• Flash Point: 188.737 °C
• Appearance: /
• Density: 1.384 g/cm³
• Vapor Pressure: 5.72E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.67±0.20(Predicted)
• CAS DataBase Reference: 3-Oxoindane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxoindane-1-carboxylic acid(29427-69-8)
• EPA Substance Registry System: 3-Oxoindane-1-carboxylic acid(29427-69-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: NK8260000
• Hazardous Substances Data: 29427-69-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 6702, 1984 DOI: 10.1021/ja00334a040

General Description

3-Oxo-1-indancarboxylic acid participates in the synthesis of 3-hydroxymethyl-1-indanol (±). Enantiomeric separation of 3-oxo-1-indancarboxylic acid on liquid chromatography chiral stationary phases (CSPs) by supercritical fluid chromatography (SFC) has been reported. Separation of 3-oxo-1-indancarboxylic acid enantiomers using a new immobilized polysaccharide chiral stationary phase, CHIRALPAK IA with hexane has been described.

InChI:InChI=1/C10H8O3/c11-9-5-8(10(12)13)6-3-1-2-4-7(6)9/h1-4,8H,5H2,(H,12,13)/p-1/t8-/m1/s1

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 1131-15-3 2-phenylsuccinic anhydride 
• 100-52-7 benzaldehyde 
• 5292-53-5 diethyl benzalmalonate 
• 14025-83-3 3-cyano-3-phenylpropanoic acid ethyl ester 
• 62-53-3 aniline 
• 70-11-1 α-bromoacetophenone 
• 70916-14-2 triethyl-(2-oxo-2-phenylethyl)ammonium bromide 
• 97301-06-9 1-Phenacyl-4-aza-1-azonia-bicyclo<2.2.2>octan-bromid 
• 24472-77-3 trimethyl-(2-oxo-2-phenylethyl)-ammonium bromide 
• 83-33-0 inden-1-one 
• 635-51-8 2-phenylsuccinic acid 
• 7664-93-9 sulfuric acid 

Downstream Products

• 60031-28-9 2-benzal-3-oxoindancarboxylic acid 
• 240403-52-5 N-<(1-oxoindan-3-yl)carbonyl>-4-(p-fluorobenzoyl)piperidine 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 470688-50-7 3-oxo-indan-1-carboxylic acid benzyl ester 
• 240403-55-8 N¹-<(1-oxoindan-3-yl)carbonyl>-N⁴-(o-methoxyphenyl)piperazine 
• 29427-70-1 methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate 
• 1444393-70-7 C₂₇H₂₈N₆O₃ 
• 921213-08-3 1-(tetrahydropyrrole-1-methyl)-2-(2,3-dihydroinden-3-one-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline 
• 2387-23-7 1,3-Dicyclohexylurea 
• 93321-72-3 2-benzyl-3-oxo-1-indancarboxylic acid 
• 29427-71-2 3-Carboxamido-1-indanon 
• 132205-76-6 1-cyano-5-chloro-2,3-dihydro-1H-indene 
• 91948-71-9 C₂₁H₂₁NO₄S 

Relevant articles and documents

Synthesis of new 6-substituted purinyl-5′-nor-1′- homocarbanucleosides based on indanol

A series of new 6-substituted purinyl-5′-nor-1′- homocarbanucleosides based on indanol were synthesized from (±)-cis-3- hydroxymethyl-1-indanol, an appropriately functionalized derivative of which was reacted with 6-chloropurine in the presence of NaH and

Preparation method and application of tetrahydroisoquinoline derivative

The invention discloses a preparation method of a tetrahydroisoquinoline derivative. The tetrahydroisoquinoline derivative is prepared by subjecting 1-(tetrapyrrolidin-1-yl)-1,2,3,4-tetrahydroisoquinoline and 2,3-dihydro-indene-3-one-1-carboxylic acid to condensation. Process conditions are optimized so that preparation steps are simplified. Agents used in the preparation are pollution free. The prepared tetrahydroisoquinoline derivative 1-(tetrapyrrolidin-1-methyl)-2-(2,3-dihydro-indene-3-one-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline can provide good calming effect against neuropathic pain.The tetrahydroisoquinoline derivative has high medical value in drug compositions for pain treatment and in replacing dependent analgesics, such as morphine.

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

Rhodium-catalyzed C-H activation of phenacyl ammonium salts assisted by an oxidizing C-N bond: A combination of experimental and theoretical studies

Rh(III)-catalyzed C-H activation assisted by an oxidizing directing group has evolved to a mild and redox-economic strategy for the construction of heterocycles. Despite the success, these coupling systems are currently limited to cleavage of an oxidizing