33695-58-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-Ethylbenzamide is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals. Its role in these industries is crucial for the development of new drugs and pesticides, contributing to advancements in healthcare and agriculture.
Used in Dye Production:
In the dye industry, 4-Ethylbenzamide is utilized in the production of dyes. Its chemical properties make it a valuable component in creating a range of colorants used in various applications, including textiles, plastics, and printing inks.
Used as a Stabilizer in the Polymer Industry:
4-Ethylbenzamide also serves as a stabilizer in the polymer industry. Its inclusion in polymer formulations helps to enhance the stability and durability of the final products, ensuring better performance and longevity in their respective applications.
Safety and Environmental Considerations:
Given the potential hazards associated with 4-Ethylbenzamide, it is essential to handle 4-ETHYLBENZAMIDE with proper safety precautions. This includes taking measures to prevent ingestion, inhalation, or skin and eye contact. Additionally, proper storage and disposal methods are necessary to minimize the risk of environmental contamination.

InChI:InChI=1/C9H11NO/c1-2-7-3-5-8(6-4-7)9(10)11/h3-6H,2H2,1H3,(H2,10,11)

Upstream product

• 16331-45-6 p-ethylbenzoyl chloride 
• 64-18-6 formic acid 
• 25309-64-2 4-ethyl-1-iodobenzene 
• 4748-78-1 4-ethylbenzylaldehyde 
• 27465-51-6 1-(4-ethylphenyl)-1-propanone 
• 123-07-9 4-Ethylphenol 
• 201230-82-2 carbon monoxide 
• 619-64-7 p-ethylbenzoic acid 
• 1118-02-1 trimethylsilyl isocyanate 
• 100-41-4 ethylbenzene 

Downstream Products

• 1361032-62-3 5-(4-ethylphenyl)-3-methyl-1-phenyl-1H-1,2,4-triazole 
• 1361032-58-7 N-acetyl-4-ethylbenzamide 

Relevant academic research and scientific papers

Ring Opening/Site Selective Cleavage in N-Acyl Glutarimide to Synthesize Primary Amides

A LiOH-promoted hydrolysis selective C-N cleavage of twisted N-acyl glutarimide for the synthesis of primary amides under mild conditions has been developed. The reaction is triggered by a ring opening of glutarimide followed by C-N cleavage to afford primary amides using 2 equiv of LiOH as the base at room temperature. The efficacy of the reactions was considered and administrated for various aryl and alkyl substituents in good yield with high selectivity. Moreover, gram-scale synthesis of primary amides using a continuous flow method was achieved. It is noted that our new methodology can apply under both batch and flow conditions for synthetic and industrial applications.

Method for preparing derivatives of benzamide under microwave condition in aqueous phase

The invention discloses a method for preparing derivatives of benzamide under a microwave condition in an aqueous phase. A coupling reaction is carried out between substituted benzoic acid and amine under the microwave condition in the aqueous phase. The method for preparing the derivatives of benzamide is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applicable to a large number of functional groups, is high in yield, produces fewer by-products, and further is easy to operate, safe, low in cost and environmentally friendly. A formula is shown in the description.

A Convenient Palladium-Catalyzed Aminocarbonylation of Aryl Iodides to Primary Amides under Gas-Free Conditions

A convenient procedure for the synthesis of aromatic primary amides through palladium-catalyzed aminocarbonylation of aryl iodides has been developed. With ammonium hydrogen carbonate as the solid nitrogen source and formic acid as the liquid CO source, a variety of primary amides were obtained in moderate to excellent yields under gas-free conditions.

Highly efficient synthesis of primary amides: Via aldoximes rearrangement in water under air atmosphere catalyzed by an ionic ruthenium pincer complex

The transformation of aldoximes to primary amides has been evaluated using pincer ruthenium complexes a-c, among which the ionic Ru catalyst a proved to be the most efficient in water under air atmosphere. A variety of (hetero)arene aldoximes proceeded smoothly to afford amides in high yields with good functional group compatibilities. Furthermore, a direct synthetic route of amides from aldehydes, hydroxylamine hydrochloride and sodium carbonate was also described with broad substrates including conjugated and aliphatic aldehydes. This protocol is operationally simple and proceeds with a low catalyst loading (0.5 mol%).

TBAI-catalyzed oxidative synthesis of benzamides from acetophenones and carbinols

An interesting and convenient procedure for the oxidative transformation of acetophenones and carbinols to primary benzamides has been developed. By using tetra-n-butylammonium iodide (TBAI) as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant, the desired benzamides were isolated in moderate to good yields in aqueous solution. Notably, not only acetophenones but also propiophenones can be applied as substrates as well. Hence, we believe that this new procedure is not just a catalytic version of the iodine-based method. the Partner Organisations 2014.

A general palladium-catalyzed aminocarbonylation of phenols to primary benzamides via in situ generation of aryl nonaflates

Amides in mind! A novel palladium-catalyzed amino-carbonylation of in situ formed aryl nonaflates to give primary amides in moderate to excellent yields has been developed (see scheme). Copyright

Electronic effects of ring substituents on triplet benzylic biradicals

UV irradiation of α-(o-alkylphenyl)acetophenones with a methoxy or cyano substituent para to the o-alkyl group of the α-aryl ring has revealed that a methoxy group slightly increases the stereoselectivity but not the quantum yield of indanol formation, whereas a cyano group greatly lowers both diastereoselectivity and quantum efficiency, confirming the likelihood that hydrogen-bonding of the hydroxy group to the α-phenyl ring plays an important role in the cyclization of the photogenerated triplet 1,5-biradical intermediates.

O-glucosylated benzamide SGLT2 inhibitors and method

SGLT2 inhibiting compounds are provided having the formula wherein n is 0, 1 or 2; A is or heteroaryl which may contain 1 to 4 heteroatoms in the ring which may be selected from N, O, S, SO, and/or SO2, bearing substituents R3 and R4; and R1 to R4 are as defined herein. A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with one, two or more other antidiabetic agents and/or one, two or more hypolipidemic agents.