33708-72-4

Usage

Uses

Used in Pharmaceutical Industry:
Pachypodol is used as a therapeutic agent for its potential to inhibit the growth of cancer cells, offering a natural alternative for cancer treatment.
Used in Diabetes Management:
Pachypodol is used as an anti-diabetic agent, helping to manage blood sugar levels and potentially reducing the risk of diabetes-related complications.
Used in Neuroprotection:
Pachypodol is used as a neuroprotective agent, potentially protecting the nervous system from damage and degeneration, which could be beneficial for conditions such as Alzheimer's and Parkinson's diseases.
Used in Cardiovascular Health:
Pachypodol is used to promote cardiovascular health, potentially reducing the risk of heart diseases and stroke due to its beneficial effects on the cardiovascular system.
Used in Drug Development:
Pachypodol is used as a key component in the development of new drugs for various medical conditions, leveraging its antioxidant, anti-inflammatory, and therapeutic properties.

InChI:InChI=1/C18H16O7/c1-22-10-7-12(20)15-14(8-10)25-17(18(24-3)16(15)21)9-4-5-11(19)13(6-9)23-2/h4-8,19-20H,1-3H3

Upstream product

• 77-78-1 dimethyl sulfate 
• 117-39-5 quercetol 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 
• 77813-31-1 2-(4-benzyloxy-3-methoxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one 
• 70390-87-3 1-(2,6-dihydroxy-4-methoxy-phenyl)-2-methoxy-ethanone 
• 854873-13-5 4-benzoyloxy-3-methoxy-benzoic acid-anhydride 

Downstream Products

• 41206-96-6 quercetin 5,4′-di-O-acetyl-3,7,3′-tri-O-methyl ether 

Relevant academic research and scientific papers

Flavonoid sulfates from the Convolvulaceae

A novel flavonoid, quercetin 7-methyl ether-3,3'-disulfate (5), was obtained from the roots of Argyreia mollis, together with the known compounds quercetin 7-methyl ether-3-sulfate (4) and kaempferol 7-methyl ether-3- sulfate (2). Two further new flavonoid sulfates, quercetin 3,7-dimethyl ether-4'-sulfate (6) and quercetin 3',4',7-trimethyl ether-3-sulfate (8), were isolated from the aerial vegetative parts of Ipomoea regnellii, together with the known compound kaempferol 4',7-dimethyl ether-3-sulfate (3). This is the first report on sulfated flavonoids in the Convolvulaceae family and, furthermore, the presence of flavonoids in A. capitata, A. mollis, I. reticulata and I. regnellii is reported for the first time.

Methylation of Quercetin by Diazomethane and Hypoglycemic Activity of its Tetra-O-Methyl Ether

The tetra-O-methyl ether of quercetin (QU) 3 (54%), 3,7,4′-tri-O-methyl ether 4 (30%), and a previously unreported 3,7,3-tri-O-methyl ether of QU 5 (7%) were obtained via methylation of QU by an excess of diazomethane in dioxane. Their structures were established using 2D NMR (1H–1H COSY, 1H–1H NOESY, 1H–13C HSQC, 1H–13C HMBC). Tetra-O-methyl ether of QU 3 exhibited pronounced hypoglycemic activity, reduced alloxan-induced hyperglycemia in rats by 44.5% compared to a control, and was 2.7 times more active than QU.

Quercetin analogs with high fetal hemoglobin-inducing activity

β-Thalassemia is the major health problems in developing countries, when affected patients and healthy carriers are numerous, resulting a total absence or severe decrease in the production of β-globin chains. The use of chemical agents for increasing the production of fetal hemoglobin (HbF) by reactivating γ-globin gene to balance excess α-globin chains is an alternative therapeutic approach. Therefore, the search for molecules exhibiting the property of inducing γ-globin gene expression is of great interest. In this report, we discovered that quercetin (1), the major flavonoid isolated from the heartwoods of the medicinal plant Anaxagorea luzonensis promoted the expression of γ-globin gene. Chemical modification of 1 to fourteen methyl ether analogs (2?15) was conducted. The structures of these compounds were established on the basis of their spectroscopic data and by comparison with those of the reported values. The parent flavonoid and its chemically modified analogs were investigated for their γ-globin gene induction for the first time. The parent compound 1 exhibited less induced γ-globin gene expression than cisplatin and hemin, the positive controls. 3,4′-Di-O-methylquercetin (7), the modified analog, significantly enhanced γ-globin gene expression with 2.6-fold change at 8 μM, which was slightly higher than cisplatin and hemin. Moreover, compounds 1 and 7 displayed less cytotoxic activity against K562::ΔGγAγEGFP cells than cisplatin. Structure-activity relationship (SAR) study revealed that the methoxyl groups at the 3- and 4?-positions and the free hydroxyl group at the 7-position are required for strong HbF-inducing activity.

3-Alkoxyflavone antiviral agents

Antiviral compositions containing 3-alkoxyflavone compounds as their active ingredients are disclosed.

The Preparation of Flavones and their Derivatives. Part I. Flavones and 4-Thioflavones.

A series of polysubstituted flavones has been prepared with particular emphasis on 3',4',5',5,7-pentahydroxyflavone and its ether derivatives.The preparation of 4-thioflavones has been undertaken to provide intermediates for the preparation of 4-iminoflav