33710-58-6

Upstream product

• 5700-56-1 1,2-diaminophenylethane 
• 536-74-3 phenylacetylene 
• 5728-14-3 4-Phenyl-3-chloro-1,2,5-thiadiazole 
• 53641-60-4 2-phenylglycinonitrile hydrochloride 
• 163430-75-9 3-benzoylformamido-4-phenyl-1,2,5-thiadiazole 

Downstream Products

• 33710-57-5 4-amino-N-(4-phenyl-[1,2,5]thiadiazol-3-yl)-benzenesulfonamide 
• 33710-56-4 4-acetylamino-N-(4-phenyl-[1,2,5]thiadiazol-3-yl)-benzenesulfonamide 

Relevant academic research and scientific papers

Reactions of Tetrasulphur Tetranitride with Alkynes; 1,4,2,6-Dithiadiazines and 1,3,2-Dithiazoles

Reaction of S4N4 with diphenylacetylene and phenylacetylene gives two new, thermally stable heterocyclic systems, the 1,4,2,6-dithiadiazine (3) and the 1,3,2-dithiazolylimine (7), respectively, as minor products; these structures, determined by X-ray diff

HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS

The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates thereof, that bind to Inhibitor of Apoptosis Proteins (IAPs). The compounds of the invention may be used as diagnostic and therapeutic agents in the

Inhibitors of IAP

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.

Reactions of Tetrasulfur Tetranitride with Aryl Dibromomethyl Ketones: One-pot Synthesis of 3-Aroylformamido-4-aryl-1,2,5-thiadiazoles and their Reactions

Heating of Dibromomethyl aryl ketones with tetrasulfur tetranitride (S4N4) at 115 deg C without a solvent gave 3-aroylformamido-4-aryl-1,2,5-thiadiazoles 8 as major products (12-71percent) and 3,5-diaroyl-1,2,4-thiadiazoles 2 as minor products in certain cases.The structures of compounds 8 were determined based on the X-ray analysis of 3-benzoylformamido-4-phenyl-1,2,5-thiadiazole 8a and comparison with an authentic sample of compound 8a, as well as all the spectroscopic and analytical data of compounds 8.Oxidation of compounds 8 with m-chloroperbenzoic acid in chloroform at room temperature gave compounds 2 (0-66percent), whereas reduction of compounds 8 with sodium boranuide in a mixture of chloroform-ethanol at room temperature gave 3-amino-4-aryl-1,2,5-thiadiazoles 10 (71-93percent).Treatment of 3-(3-nitrobenzoylformamido)-4-(3-nitrophenyl)-1,2,5-thiadiazole 8d with either sodium hydroxide in aqueous p-dioxane at reflux or sodium hydride in chloroform at room temperature gave 3-amino-4-(3-nitrophenyl)-1,2,5-thiadiazole 10d in 56 and 80percent yield, respectively.