5700-56-1

Usage

Uses

Used in Pharmaceutical Industry:
1-PHENYL-ETHANE-1,2-DIAMINE is used as an organic intermediate for the synthesis of various pharmaceuticals. Its presence in the production process aids in the creation of different medicinal compounds, contributing to the development of new drugs and treatments.
Used in Agrochemical Industry:
1-PHENYL-ETHANE-1,2-DIAMINE is used as an organic intermediate in the production of agrochemicals. It plays a role in the synthesis of various agricultural chemicals, such as pesticides and herbicides, which are essential for crop protection and increased agricultural productivity.
Used in Dye Industry:
1-PHENYL-ETHANE-1,2-DIAMINE is used as an organic intermediate in the manufacturing of dyestuffs. Its involvement in the synthesis process helps in the creation of a wide range of dyes used in various industries, including textiles, plastics, and printing inks, for coloration purposes.

InChI:InChI=1/C8H12N2/c9-6-8(10)7-4-2-1-3-5-7/h1-5,8H,6,9-10H2

Upstream product

• 7707-64-4 3-phenyl-furazan 5-oxide 
• 28236-68-2 3-phenyl-furazan 2-oxide 
• 64-17-5 ethanol 
• 17016-15-8 anti-phenylglyoxime 
• 825-52-5 2-(hydroxyimino)-2-phenylacetonitrile 
• 16750-42-8 2-amino-2-phenylacetonitrile 
• 700-63-0 Phenylglycinamid 
• 27129-49-3 4-phenylimidazolidin-2-one 
• 22710-73-2 1,2-diazido-1-phenylethane 
• 28438-00-8 2-methyl-4-phenyl-4,5-dihydro-imidazole-1-carboxylic acid amide 
• 142563-73-3 (Z)-2-azido-1-phenylethanone O-methyloxime 
• 7647-01-0 hydrogenchloride 
• 26527-40-2 phenylglyoxal-(1Z,2E)-dioxime 
• 100-42-5 styrene 

Downstream Products

• 62779-70-8 (1S)-1-phenylethylene-1,2-diamine 
• 62779-69-5 (R)-1,2-Diamino-1-phenylethane 
• 53641-61-5 1-phenyl-1-acetylamino-2-acetylaminoethane 
• 95006-06-7 N,N'-(phenyl-ethanediyl)-bis-benzamide 
• 16670-17-0 (1-phenyl-ethanediyldiimino)-tetra-acetic acid 
• 66042-89-5 2,5,6-triphenyl-2,3-dihydro-pyrazine 
• 28438-04-2 2-methyl-4-phenyl-4,5-dihydro-1⁽³⁾H-imidazole 
• 61796-78-9 Undec-10-enoic acid (1-phenyl-2-undec-10-enoylamino-ethyl)-amide 
• 61796-88-1 2-Ethyl-N-[2-(2-ethyl-butyrylamino)-1-phenyl-ethyl]-butyramide 
• 4057-62-9 3-phenyl-1,2,5-thiadiazole 
• 33710-58-6 3-amino-4-phenyl-1,2,5-thiadiazole 
• 49704-08-7 4-phenyl-4,5-dihydro-1H-imidazol-2-thione 
• 79592-40-8 (6R,7R)-3-Methyl-8-oxo-7-(4-phenyl-4,5-dihydro-1H-imidazol-2-ylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 7667-39-2 2-phenyl-benzo[f]quinoxaline 

Relevant academic research and scientific papers

Palladium-Catalyzed Intermolecular Oxidative Diazidation of Alkenes

A palladium-catalyzed oxidative vicinal diazidation of alkenes has been developed, in which TMSN3 was used as azide source. Both styrenes and unactivated alkenes are suitable for this reaction. And trans-alkyldiazides were obtained as major products from cyclic alkenes with moderate to good diastereoselectivities. This reaction afforded an efficient way for the synthesis of useful 1,2-diamines after hydrogenation.

One-pot protocol to synthesize N-(β-nitro)amides by tandem Henry/Ritter reaction

A novel, efficient and atom economical one pot protocol for the synthesis of N-(β-nitro)amides has been described by combining the Henry reaction with the Ritter reaction. The designed products could be obtained from easily available aldehydes, nitroalkan

Three-Component Azidation of Styrene-Type Double Bonds: Light-Switchable Behavior of a Copper Photoredox Catalyst

[Cu(dap)2]Cl effectively catalyzes azide addition from the Zhdankin reagent to styrene-type double bonds, and subsequent addition of a third component to the benzylic position. In the presence of light, a photoredox cycle is implicated with pol

Iodine(III)-promoted intermolecular diamination of alkenes

A rapid and productive vicinal diamination of alkenes takes place in the presence of a hypervalent iodine(III) reagent and bissulfonimides as nitrogen sources. A total of more than 60 examples are presented. The reaction is characterized by its robustness and its wide substrate scope: it proceeds selectively with both terminal and internal alkenes and tolerates a range of functional groups.

COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USES AS IDH1 MUTANTS INHIBITORS FOR TREATING CANCERS

Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses as IDH1 mutants inhibitors for treating cancers are also provided

ORGANIC COMPOUNDS

The present invention provides heterocyclicderivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Method of making imidazole-2-thiones

The present invention provides a method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine with a compound having a thiocarbonyl moiety and oxidizing the resulting reaction product to obtain said imidazole-2-thione.

Convenient method for one-pot preparation of 1,2-diamines from nitroolefins

Convenient method for preparation of 1,2-diamine from the corresponding nitroolefin was established by successive reactions of Michael addition of O-ethylhydroxylamine to nitroolefin and reduction with hydrogen. The present preparative method was applicable to various nitroolefins by one-pot procedure.

Use of α-Bromo Oxime Ethers in the Synthesis of 1,2-Diamines

Oxime ethers 1 react with ammonia and primary amines to give α-amino oxime ethers.The reaction of α-bromo oxime ethers with sodium azide affords α-azido oxime ethers.Hydrogenolysis of the azido compounds using 5percent palladium on calcium carbonate as catalyst yields the α-amino oxime ethers.The reaction of α-azido oxime ethers with lithium aluminum hydride gives 1,2-ethanediamine derivatives.The reaction of azido oxime ether 13 with LiAlH4, and subsequently the reaction of the resulting mixture of the diamines 14 and 15 with phosgene, preferably gives cis-4-pentyl-5-methyl-2-imidazolidone (16) indicating that the reduction of 13 proceeds in a stereoselective manner to furnish mainly the syn-1,2-ethanediamine 15. Key Words: Oxime ethers / α-Azido oxime ethers / α-Amino oxime ethers / 1,2-Ethanediamines

Benzodioxane-imidazoline compounds as antihypertensives

Compounds of the formula STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein: n is an integer equal to 0, 1, 2 or 3; R1 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenyl lower alkyl; each R is independently hydrogen, lower alkyl, optionally substituted phenyl, or optionally substituted phenyl lower alkyl; are α2 blockers, and, therefore, are useful in treating essential hypertension and depression, and in inhibiting platelet aggregation.