33717-87-2

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Oxaspiro[2.5]octane-2-carboxylic acid, methyl ester (7CI, 8CI, 9CI) is used as an intermediate in the synthesis of pharmaceuticals for its unique chemical structure and potential biological activity. It plays a crucial role in the development of new drugs with improved efficacy and safety profiles.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1-Oxaspiro[2.5]octane-2-carboxylic acid, methyl ester (7CI, 8CI, 9CI) is utilized as a key component in the synthesis of various agrochemicals. Its incorporation aids in the development of innovative products with enhanced performance and reduced environmental impact.
Used in Organic Compound Synthesis:
1-Oxaspiro[2.5]octane-2-carboxylic acid, methyl ester (7CI, 8CI, 9CI) is also employed in the synthesis of other organic compounds, showcasing its versatility and potential applications across a wide range of chemical processes. Its unique structure allows for the creation of novel compounds with diverse properties and uses.
Used in Drug Development Research:
Due to its promising biological activity demonstrated in certain research studies, 1-Oxaspiro[2.5]octane-2-carboxylic acid, methyl ester (7CI, 8CI, 9CI) is used as a subject of investigation in drug development research. Scientists explore its potential applications in treating various diseases and conditions, aiming to harness its unique properties for therapeutic benefits.

InChI:InChI=1/C9H14O3/c1-11-8(10)7-9(12-7)5-3-2-4-6-9/h7H,2-6H2,1H3

Upstream product

• 116-54-1 dichloroacetic acid methyl ester 
• 108-94-1 cyclohexanone 
• 865-47-4 potassium tert-butylate 
• 96-34-4 methyl chloroacetate 
• 186581-53-3 diazomethane 
• 6190-79-0 1-oxa-spiro-[2,5]octane-2-carboxylic acid 

Downstream Products

• 25957-47-5 Sodium; 1-oxa-spiro[2.5]octane-2-carboxylate 
• 99334-06-2 rac-2-cyclohexenyl-2-hydroxyethanoic acid methyl ester 
• 2043-61-0 cyclohexanecarbaldehyde 

Relevant academic research and scientific papers

Carboxylate-stabilised sulfur ylides (thetin salts) in asymmetric epoxidation for the synthesis of glycidic acids. Mechanism and implications

The reaction of carboxylate-stabilised sulfur ylides (thetin salts) with aldehydes and ketones has been investigated. Using both achiral and chiral sulfur ylides, good yields were obtained with dimsylsodium or LHMDS as bases in DMSO or THF-DMSO mixtures.

3-Hydroxy-2-oxo-1-oxaspiro[4.5]-dec-3-ene, a new inhibitor of lactate dehydrogenase

Methods for the synthesis of the spirolactone [3-hydroxy-2-oxo-1-oxaspiro[4.5]-dec-3-ene, 3] and the sodium salts of two new α-keto acids [(1-cyclohexenyl)glyoxylate 1, β-(1-hydroxycyclohexane)pyruvate (enol form, 2)] are described. These compounds are ex

A convenient synthesis of aziridine-2-carboxylic esters

Optically active oxirane-2-carboxylic esters, prepared from allylic alcohols employing the Sharpless epoxidation, were treated with sodium azide.The azido alcohols obtained were subsequently converted into aziridine-2-carboxylic esters by reaction with triphenylphosphine, in good yields and with high optical purity.Various racemic oxirane-2-carboxylic esters were subjected to the same sequence of reactions.

Metal Exchange between an Electrogenerated Organonickel Species and Zinc Halide: Application to an Electrochemical, Nickel-Catalyzed Reformatsky Reaction

The mechanism of the electroreductive coupling of α-chloro esters or α-chloro nitriles with carbonyl compounds by the means of a sacrificial zinc anode and a nickel catalyst was elucidated by electroanalytical techniques.The mechanism involved reduction of a Ni(II) complex to a Ni(0) complex, oxidative addition of the α-chloro ester to the Ni(0) complex, and a Zn(II)/Ni(II) exchange, leading to an organozinc Reformatsky reagent.The electrosynthesis of various β-hydroxy esters, β-hydroxy nitriles, and 2,3-epoxy esters was successfully achieved under extremely mild conditions.

ELECTROREDUCTIVE COUPLING OF METALLYLCHLORIDE OR METHYL CHLOROACETATE WITH CARBONYL COMPOUNDS CAATLYZED BY NICKEL BIPYRIDINE COMPLEXES

An efficient electrosynthesis of homoallyl alcohols or β-hydroxy esters in the presence of catalytic amounts of the NiBr2(2,2'-bipyridine) complex has been developed from mixed electrolysis of metellylchloride, or methyl chloroacetate with several carbonyl compounds, using a one-compartment cell equiped with a sacrificial zinc anode.