99334-06-2

Upstream product

• 33717-87-2 1-oxa-spiro-[2,5]octane-2-carboxylic acid methyl ester 
• 98593-11-4 Cyclohex-1-enyl-hydroxy-acetonitrile 
• 1192-88-7 1-cyclohexene-1-carboxaldehyde 

Downstream Products

• 69455-34-1 rac-2-cyclohexenyl-2-hydroxyethanoic acid 
• 65499-26-5 methyl 2-(cyclohex-1-en-1-yl)-2-oxoacetate 

Relevant academic research and scientific papers

The substrate spectrum of mandelate racemase: Minimum structural requirements for substrates and substrate model

Mandelate racemase (EC 5.1.2.2) is one of the few biochemically well-characterized racemases. The remarkable stability of this cofactor-independent enzyme and its broad substrate tolerance make it an ideal candidate for the racemization of non-natural α-hydroxycarboxylic acids under physiological reaction conditions to be applied in deracemization protocols in connection with a kinetic resolution step. This review summarizes all aspects of mandelate racemase relevant for the application of this enzyme in preparative-scale biotransformations with special emphasis on its substrate tolerance. Collection and evaluation of substrate structure-activity data led to a set of general guidelines, which were used as basis for the construction of a general substrate model, which allows a quick estimation of the expected activity for a given substrate.

3-Hydroxy-2-oxo-1-oxaspiro[4.5]-dec-3-ene, a new inhibitor of lactate dehydrogenase

Methods for the synthesis of the spirolactone [3-hydroxy-2-oxo-1-oxaspiro[4.5]-dec-3-ene, 3] and the sodium salts of two new α-keto acids [(1-cyclohexenyl)glyoxylate 1, β-(1-hydroxycyclohexane)pyruvate (enol form, 2)] are described. These compounds are ex

Selective Isomerization of Glycidates and Their Analogues with Triphenylsilyl Perchlorate or Electrogenerated Acid

Isomerization of glycidic esters and nitriles to the corresponding 2-hydroxy-3-alkenoates and their nitrile derivatives occurred on treatment with triphenylsilyl perchlorate or electrogenerated acid (EG acid).The cyanohydrin moiety of the nitriles 4 was transformed to a formyl group, giving the corresponding enals on treatment with weak base.

Catalyst and method for isomerization

A catalyst for isomerization consisting essentially of a salt or complex salt represented by the formula: where M is a metal of Group IB, IIA, IIB or VIII of the periodic table, L is a ligand, Y is a conjugated base of a Bronsted acid, m is 0, 1, 2, 3 or 4 and n is 1, 2 or 3.