33719-42-5Relevant academic research and scientific papers
Synthesis of dichlorophenyl-, cyanophenyl-and quinolinyl-substituted α-ethoxyacetic acids and derivatives, via α-hydroxyarylacetic acids
Gutteridge, Clare E.,Curtis, Sean M.,Major, Joshua W.,Nin, Daniel A.,Bhattacharjee, Apurba K.,Nichols, Daniel A.,Gerena, Lucia
, p. 407 - 412 (2016/03/25)
A synthetic approach to novel series of α-ethoxy-α-phenylacetamides and α-ethoxy-α-quinolinylacetamides was developed. Aryl aldehydes were converted to cyanohydrins, which were then hydrolyzed or alcoholyzed. Following ethylation of the α-hydroxy group, p
Kinetics and mechanism of vanadium catalysed asymmetric cyanohydrin synthesis in propylene carbonate
North, Michael,Omedes-Pujol, Marta
experimental part, p. 1043 - 1055 (2011/03/22)
Propylene carbonate can be used as a green solvent for the asymmetric synthesis of cyanohydrin trimethylsilyl ethers from aldehydes and trimethylsilyl cyanide catalysed by VO(salen)NCS, though reactions are slower in this solvent than the corresponding re
A new (R)-hydroxynitrile lyase from Prunus mume: Asymmetric synthesis of cyanohydrins
Nanda, Samik,Kato, Yasuo,Asano, Yasuhisa
, p. 10908 - 10916 (2007/10/03)
A new hydroxynitrile lyase (HNL) was isolated from the seed of Japanese apricot (Prunus mume). The enzyme has similar properties with HNL isolated from other Prunus species and is FAD containing enzyme. It accepts a large number of unnatural substrates (benzaldehyde and its variant) for the addition of HCN to produce the corresponding cyanohydrins in excellent optical and chemical yields. A new HPLC based enantioselective assay technique was developed for the enzyme, which promotes the addition of KCN to benzaldehyde in a buffered solution (pH=4.5).
SUBSTITUTED ARYLALIPHATIC COMPOUNDS, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT
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, (2008/06/13)
Compound of Formula (I), wherein W 1 is an oxygen atom; an--NR--group wherein R is hydrogen, C 1-C 7 alkyl or benzyl; and B is for example a substituted piperidine or quinuclidine. The disclosed compounds are useful as neurokinin receptor antagonists.
Enzymatic Preparation of Optically Active Cyanohydrin Acetates
Almsick, Andreas van,Buddrus, Joachim,Hoenicke-Schmidt, Petra,Laumen, Kurt,Schneider, Manfred P.
, p. 1391 - 1393 (2007/10/02)
A series of cyanohydrin acetates (1)-(47) of widely varying structures, potential chiral building blocks for numerous synthetic applications, has been prepared in good chemical and often high optical yields by enzymatic hydrolysis of their racemic acetates in the presence of an ester hydrolase from Pseudomonas sp.
