95392-03-3

Basic information

• Product Name: (3,4-Dichloro-phenyl)-trimethylsilanyloxy-acetonitrile
• Synonyms: (3,4-Dichloro-phenyl)-trimethylsilanyloxy-acetonitrile
• CAS NO: 95392-03-3
• Molecular Formula: C₁₁H₁₃Cl₂NOSi
• Molecular Weight: 0
• Mol File: 95392-03-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3,4-Dichloro-phenyl)-trimethylsilanyloxy-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-Dichloro-phenyl)-trimethylsilanyloxy-acetonitrile(95392-03-3)
• EPA Substance Registry System: (3,4-Dichloro-phenyl)-trimethylsilanyloxy-acetonitrile(95392-03-3)

Safety Data

• Hazardous Substances Data: 95392-03-3(Hazardous Substances Data)

Usage

General Description

(3,4-Dichloro-phenyl)-trimethylsilanyloxy-acetonitrile is a chemical compound that contains a chloro-phenyl group, a trimethylsilyloxy group, and an acetonitrile group. It is commonly used as a reagent in organic synthesis due to its ability to react with various functional groups. The trimethylsilyloxy group, which is a silyl ether, can be used to protect alcohols and phenols in organic reactions. The acetonitrile group, on the other hand, is a versatile functional group that can undergo various reactions such as nucleophilic addition and substitution. The presence of the dichloro-phenyl group also provides unique reactivity, making this compound a useful intermediate in the synthesis of pharmaceuticals and agrochemicals. However, it is important to handle this chemical with caution, as it may be hazardous if not properly handled and stored.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 177755-45-2 2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile 

Downstream Products

• 177755-55-4 1-(3,4-dichlorophenyl)-2-hydroxy-2-[4-(methylthio)phenyl]ethanone 
• 93534-22-6 1-(3,4-dichlorophenyl)-2-phenyl-ethan-1-one 
• 157672-03-2 1-(4-methylphenyl)-2-[4-(methylthio)phenyl]ethane-1,2,-dione 
• 177755-73-6 2-hydroxy-2-(4-methylthiophenyl)-1-phenylethanone 
• 58022-58-5 1-(4-methylsulfanylphenyl)-2-phenyl-1,2-ethanedione 
• 177754-55-1 4-[4-(methylsulfonyl)phenyl]-5-(2-naphthyl)-2-(trifluoromethyl)-1H-imidazole 
• 177755-60-1 4-[4-(methylthio)phenyl]-5-(2-naphthyl)-2-(trifluoromethyl)-1H-imidazole 
• 177755-57-6 5-(3,4-dichlorophenyl)-4-[4-(methylthio)phenyl]-2-(trifluoromethyl)-1H-imidazole 
• 177755-59-8 2-[4-(methylthio)phenyl]-1-(2-naphthyl)ethane-1,2-dione 
• 177755-58-7 2-hydroxy-2-[4-(methylthio)phenyl]-1-(2-naphthyl)ethanone 
• 177755-56-5 1-(3,4-dichlorophenyl)-2-[4-(methylthio)phenyl]ethane-1,2-dione 
• 95392-15-7 2-(3,4-Dichloro-phenyl)-2-fluoro-ethylamine; hydrochloride 
• 33719-42-5 2-(3,4-dichlorophenyl)-2-hydroxyacetonitrile 
• 95392-09-9 2-(3,4-dichlorophenyl)-2-fluoroacetonitrile 

Relevant articles and documents

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.

Kinetics and mechanism of the racemic addition of trimethylsilyl cyanide to aldehydes catalysed by Lewis bases

The mechanism by which four Lewis bases, triethylamine, tetrabutylammonium thiocyanate, tetrabutylammonium azide and tetrabutylammonium cyanide, catalyse the addition of trimethylsilyl cyanide to aldehydes is studied by a combination of kinetic and spectr

Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation

A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II STR1 wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower aralkenyl, lower aryloxyalkyl, lower arylthioalkyl and heteroaryl; wherein R3 is selected from lower alkyl and amino; and wherein R4 is one or more radicals selected from hydrido, halo, lower alkyl and lower alkoxy; or where R4 together with the phenyl radical forms naphthyl or benzodioxolyl; provided R1 is not lower alkyl when R3 is methyl and when R4 is hydrido, methyl, methoxy or chloro; or a pharmaceutically-acceptable salt thereof.