337355-95-0Relevant academic research and scientific papers
Baylis-Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents
Batra,Roy,Patra,Bhaduri,Surin,Raghavan,Sharma,Kapoor,Dikshit
, p. 2059 - 2077 (2007/10/03)
The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.
The Baylis-Hillman chemistry in aqueous media: Elucidation of mechanism for synthesis of ether side-product leads to an efficient approach to C-O bond formation
Patra,Roy,Joshi,Roy,Batra,Bhaduri
, p. 663 - 670 (2007/10/03)
The formation of an ether from the Baylis-Hillman (BH) adduct during the BH reaction of 5-isoxazolecarboxaldehydes is a common phenomenon if the reaction is allowed to proceed for longer periods. The amount of formation of such ethers depends on the acryl
5-Isoxazolecarboxaldehyde: A novel substrate for fast Baylis-Hillman reaction
Patra,Batra,Kundu,Joshi,Roy,Bhaduri
, p. 276 - 280 (2007/10/03)
3-Aryl-5-isoxazolecarboxaldehyde undergoes fast Baylis-Hillman reaction with a variety of activated alkenes to yield the corresponding adducts in excellent yields. Some of the Baylis-Hillman adducts reported herein have been subsequently modified to obtai
