337356-03-3

Basic information

• Product Name: 5-Isoxazolepropanenitrile, b-hydroxy-a-methylene-3-phenyl-
• CAS NO: 337356-03-3
• Molecular Formula: C13H10N2O2
• Molecular Weight: 226.235
• Mol File: 337356-03-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Isoxazolepropanenitrile, b-hydroxy-a-methylene-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Isoxazolepropanenitrile, b-hydroxy-a-methylene-3-phenyl-(337356-03-3)
• EPA Substance Registry System: 5-Isoxazolepropanenitrile, b-hydroxy-a-methylene-3-phenyl-(337356-03-3)

Safety Data

• Hazardous Substances Data: 337356-03-3(Hazardous Substances Data)

Upstream product

• 72418-40-7 3-phenylisoxazole-5-carbaldehyde 
• 107-13-1 acrylonitrile 

Downstream Products

• 852287-75-3 2-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-3-(3-phenyl-isoxazol-5-yl)-propionitrile 
• 852287-99-1 [2-amino-1-(4-fluoro-benzyl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-(3-phenyl-isoxazol-5-yl)-methanol 
• 852287-87-7 2-aminomethyl-3-(4-fluoro-benzylamino)-1-(3-phenyl-isoxazol-5-yl)-propan-1-ol 
• 852287-82-2 2-aminomethyl-3-benzylamino-1-(3-phenyl-isoxazol-5-yl)-propan-1-ol 
• 852287-70-8 2-(benzylamino-methyl)-3-hydroxy-3-(3-phenyl-isoxazol-5-yl)-propionitrile 
• 503073-46-9 acetic acid 2-cyano-1-(3-phenyl-isoxazol-5-yl)-allyl ester 

Relevant articles and documents

Baylis-Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.