72418-40-7

Basic information

• Product Name: 3-Phenylisoxazole-5-carboxaldehyde 97%
• Synonyms: 3-Phenylisoxazole-5-carboxaldehyde 97%;3-PHENYLISOXAZOLE-5-CARBALDEHYDE;3-Phenylisoxazole-5-carboxaldehyde;5-isoxazolecarboxaldehyde, 3-phenyl-;3-phenyl-5-isoxazolecarbaldehyde(SALTDATA: FREE);3-phenyl-1,2-oxazole-5-carbaldehyde;3-phenyl-5-isoxazolecarboxaldehyde;3-Phenylisoxazole-5-carboxaldehyde97%
• CAS NO: 72418-40-7
• Molecular Formula: C₁₀H₇NO₂
• Molecular Weight: 173.17
• Mol File: 72418-40-7.mol

Chemical Properties

• Melting Point: 72.5-74°C
• Boiling Point: 361.5 °C at 760 mmHg
• Flash Point: 172.4 °C
• Appearance: /
• Density: 1.216 g/cm³
• Vapor Pressure: 2.06E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Phenylisoxazole-5-carboxaldehyde 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenylisoxazole-5-carboxaldehyde 97%(72418-40-7)
• EPA Substance Registry System: 3-Phenylisoxazole-5-carboxaldehyde 97%(72418-40-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 72418-40-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
3-Phenylisoxazole-5-carboxaldehyde 97% is used as a building block for synthesizing more complex organic molecules due to its unique chemical properties, including the aromatic phenyl group and the aldehyde functional group.
Used in Medicinal Chemistry:
3-Phenylisoxazole-5-carboxaldehyde 97% is used as a reagent in chemical reactions to create molecules with potential applications in medicine, such as the development of new pharmaceutical compounds.
Used in Chemical Research and Development:
3-Phenylisoxazole-5-carboxaldehyde 97% is utilized in chemical research and development to explore its properties and potential applications in various scientific fields, including the synthesis of novel compounds and the study of reaction mechanisms.

InChI:InChI=1/C10H7NO2/c12-7-9-6-10(11-13-9)8-4-2-1-3-5-8/h1-7H

Upstream product

• 624-67-9 Propargylic aldehyde 
• 873-67-6 benzonitrile oxide 
• 932-90-1 Benzaldoxime 
• 100-52-7 benzaldehyde 
• 90924-12-2 3-phenyl-5-hydroxymethylisoxazole 
• 5221-17-0 2,3-dibromopropanal 
• 81745-44-0 benzohydroximoyl chloride 
• 135335-38-5 5-dichloromethyl-3-phenyl-isoxazole 

Downstream Products

• 1198212-40-6 2-hydroxy-2-(3-phenylisoxazol-5-yl)acetonitrile 
• 72418-42-9 oxo-(3-phenyl-isoxazol-5-yl)-acetaldehyde oxime 

Relevant articles and documents

A rapid and efficient solvent-free microwave-assisted synthesis of pyrazolone derivatives containing substituted isoxazole ring

An efficient synthesis of 4-substituted pyrazolone derivatives was developed. 4-Substituted pyrazolone derivatives were synthesized in 78-97% yields starting from various 3-substituted isoxazole-5-carbaldehydes, ethyl acetoacetate and hydrazine under micr

Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation

An efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98 %). Solid support SiO2 was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring were synthesized via this method in excellent yields (> 94 %) using 3-substituted isoxazole-5-carbaldehydes and indole.

Synthesis of novel 5-(3-alkylquinolin-2-yl)-3-aryl isoxazole derivatives and their cytotoxic activity

The propargyl alcohol on reaction with aldoxime and NaOCl in DCM gave exclusively (3-arylisoxazol-5-yl) methanol 1. The compound 1 was oxidized to an aldehyde 2 followed by reaction with aniline resulted in Schiff's base 3. The compounds 3 were further re

GLYCINE TRANSPORTER INHIBITING SUBSTANCES

The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder:

Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings

Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcus aureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.

PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF

A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

Construction of two vicinal quaternary carbons by asymmetric allylic alkylation: Total synthesis of hyperolactone C and (-)-biyouyanagin A

Call on triple A: Palladium-catalyzed asymmetric allylic alkylation (Pd-AAA; see scheme) has enabled a concise and efficient synthesis of hyperolacto ne C and (-)-biyouyanagin A in only six (20% Overall yield) and seven (8% overall yield) steps, respectively. The enantiomers of these natural products were also prepared by exploiting the same methodology.

Efficient access to isoxazoles from alkenes

The direct regioselective synthesis of 3,5-disubstituted isoxazoles was achieved in one reaction vessel through a sequence of reactions involving the net bromination of an electron-deficient alkene, in situ generation of a nitrile oxide, 1,3-dipolar cycloaddition, and loss of HBr from an intermediate 5,5-disubstituted bromoisoxazoline. This one-pot process enables the synthesis of 3,5-disubstituted isoxazoles directly from electron-deficient alkenes thereby negating the isolation of the 1,1-disubstituted bromoalkene alkyne surrogate. Georg Thieme Verlag Stuttgart.