337356-20-4

Upstream product

• 75-36-5 acetyl chloride 
• 337356-01-1 2-{[3-(4-benzyloxy-phenyl)-isoxazol-5-yl]-hydroxy-methyl}-acrylic acid tert-butyl ester 
• 1663-39-4 tert-Butyl acrylate 
• 337355-81-4 3-(4-benzyloxy-phenyl)-isoxazol-5-carbaldehyde 

Downstream Products

• 337356-28-2 2-[1-[3-(4-Benzyloxy-phenyl)-isoxazol-5-yl]-meth-(E)-ylidene]-5-oxo-hexanoic acid tert-butyl ester 
• 337356-33-9 2-[1-[3-(4-Benzyloxy-phenyl)-isoxazol-5-yl]-meth-(E)-ylidene]-5-oxo-hexanoic acid 

Relevant academic research and scientific papers

Isoxazole-based derivatives from Baylis-Hillman chemistry: Assessment of preliminary hypolipidemic activity

The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described.

5-Isoxazolecarboxaldehyde: A novel substrate for fast Baylis-Hillman reaction

3-Aryl-5-isoxazolecarboxaldehyde undergoes fast Baylis-Hillman reaction with a variety of activated alkenes to yield the corresponding adducts in excellent yields. Some of the Baylis-Hillman adducts reported herein have been subsequently modified to obtai