337378-45-7

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 14527-26-5 2-methylisothiourea sulphate 
• 141-97-9 ethyl acetoacetate 
• 154866-92-9 ethyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1236204-35-5 ethyl 4-(4-chlorophenyl)-6-methyl-2-(methylthio)pyrimidine-5-carboxylate 
• 1476039-79-8 ethyl 4-(4-chlorophenyl)-2-(dimethylamino)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1117816-31-5 C₃₀H₂₂Cl₂N₄O₄ 
• 1412900-79-8 ethyl 3-(5-bromo-benzofuran-2-carbonyl)-5-(4-chlorophenyl)-7-methyl-1-phenyl-1,5-dihydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate 

Relevant academic research and scientific papers

Synthesis, molecular docking, and cardioprotective activity of 2-methylthio-1,4-dihydropyrimidines

A series of 2-methylthio-1,4-dihydropyrimidine derivatives (IIa-IIl) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (Ia-Il) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analys

Efficient aerobic oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines

4-Substituted dihydropyrimidinones and dihydropyrimidines were first efficient aerobic oxidized to the corresponding pyrimidinones and pyrimidines, respectively, in high yields by molecular oxygen in the presence of catalytic amount of N-hydroxyphthalimid

Mild and efficient oxidative aromatization of 4-substituted-1,4- dihydropyrimidines using (diacetoxyiodo)benzene

(Chemical Equation Presented) 4-Alkyl or aryl-1,4-dihydropyrimidines were readily oxidized by (diacetoxyiodo)benzene under mild reaction conditions to the corresponding pyrimidine derivatives in good to excellent yields.

Synthesis and anti-hypertensive activity of some dihydropyrimidines

Wide range of biological activities are associated with 1,4-dihydropyridines/pyrimidines, individually or in combination. In view of the synthesis of various 6-methyl-4-substitutedphenyl-2-thioxo-1,2,3,4- tetrahydropyrimidine-5-carboxylic acid ethyl esters and 6-methyl-4-substituted phenyl-2-S-alkyl(benzyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl esters was undertaken for synthesizing biologically active molecules with improved activity, lesser toxicity with undesirable side effects in clinical use. The synthesized compounds have been tested for anti-hypertensive activity and show some new results about the structure-activity relationship contrary to an earlier reports.