33738-96-4

Basic information

• Product Name: 2,2-bis(4-mehoxyphenyl)-4-(2,2-bis-(4-methoxyphenyl)vinyl)-6-nitrochromane
• Synonyms: 2,2-bis(4-mehoxyphenyl)-4-(2,2-bis-(4-methoxyphenyl)vinyl)-6-nitrochromane
• CAS NO: 33738-96-4
• Molecular Weight: 514.667
• Mol File: 33738-96-4.mol

Chemical Properties

• CAS DataBase Reference: 2,2-bis(4-mehoxyphenyl)-4-(2,2-bis-(4-methoxyphenyl)vinyl)-6-nitrochromane(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-bis(4-mehoxyphenyl)-4-(2,2-bis-(4-methoxyphenyl)vinyl)-6-nitrochromane(33738-96-4)
• EPA Substance Registry System: 2,2-bis(4-mehoxyphenyl)-4-(2,2-bis-(4-methoxyphenyl)vinyl)-6-nitrochromane(33738-96-4)

Safety Data

• Hazardous Substances Data: 33738-96-4(Hazardous Substances Data)

Upstream product

• 530-48-3 1,1-Diphenylethylene 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 149-73-5 trimethyl orthoformate 

Relevant articles and documents

Access to Electron-Deficient 2,2-Disubstituted Chromanes: A Highly Regioselective One-Pot Synthesis via an Inverse-Electron-Demand [4 + 2] Cycloaddition of ortho-Quinone Methides

We report the one-pot synthesis of 2,2-disubstituted chromanes with electron-withdrawing substituents. This reaction provides a simple yet efficient route to a wide range of electron-deficient chromanes in high yield and excellent regioselectivity. The reaction of salicylaldehyde with 1,1-disubstituted ethylenes smoothly furnishes these electron-deficient chromanes, which can be further transformed into functionalized chromanes or chromene. For example, BW683C was effectively synthesized from 5-chlorosalicylaldehyde with 4-chlorostyrene in two steps in excellent yield. The present reaction thus provides versatile access to functionalized electron-deficient chromanes and chromenes and therefore constitutes a promising tool for the synthesis of biologically and photochemically active molecules.

Temperature-controlled divergent synthesis of 4-alkoxy- or 4-alkenyl-chromanes via inverse electron-demand cycloaddition with in situ generated ortho-quinone methides

The temperature-controlled divergent synthesis of 4-alkoxy- or 4-alkenyl-chromanes via inverse electron-demand cycloaddition with in situ generated ortho-quinone methides under identical reaction conditions except for thermal condition has been developed. At room temperature, the reaction generated 4-methoxychromanes, whereas the reaction performed at room temperature to 100 °C gave 4-alkenylchromanes. Trifluoromethanesulfonic acid was efficiently suitable in the reaction to give the 4-substituted chromanes. This divergent synthetic strategy exhibits a new method giving carbon–carbon or carbon–oxygen bond by controlling the reaction temperature.