337512-10-4

Upstream product

• 67382-35-8 (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one 
• 100-34-5 benzene diazonium chloride 
• 62-53-3 aniline 

Downstream Products

• 50610-93-0 (1RS,2SR)-2-benzoylamino-1-phenyl-propane-1,3-diol 
• 3313-16-4 (1RS,2SR)-2-benzoylamino-1,3-bis-benzoyloxy-1-phenyl-propane 
• 1055324-47-4 6-p-chlorobenzoyl-2-phenyl-2,3-dihydropyridazine-4-carbonitrile 
• 4410-31-5 (RS)-mandelamide 
• 3306-06-7 (1RS,2SR)-2-amino-1-phenyl-propane-1,3-diol 

Relevant academic research and scientific papers

Arylhydrazonals as the aldehyde component in Baylis-Hillman reactions

Arylhydrazonals were added to acrylonitrile or methyl vinyl ketone in the presence of DABCO or benzotriazole to yield the intermediate Baylis-Hillman adduct that cyclized under the reaction conditions with water elimination to yield dihydropyridazines. A pyridazine reacted with DMAD to yield a pyridine via a [4+2] Diels-Alder addition followed by retro Diels-Alder elimination of methylene aniline. Two pyridazines were condensed with DMFDMA to yield the corresponding enaminones that reacted with NH2NH2 to afford the pyrazolylpyridazines.

Efficient synthesis of 3-aroylcinnolines from aryl methyl ketones

An efficient synthesis of 3-aroylcinnolines starting from the appropriate aryl methyl ketones is described. The latter were converted in two steps to the corresponding 3-oxo-3-aryl-2-arylhydrazonopropanals, which upon acid catalyzed cyclization in conc. s