337522-95-9Relevant academic research and scientific papers
On the effect of ring substituents in the carbonylation of aziridines
Davoli, Paolo,Forni, Arrigo,Moretti, Irene,Prati, Fabio,Torre, Giovanni
, p. 1801 - 1812 (2001)
The effect of ring substituents on the cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to β-lactams has been investigated. A variety of aziridines with different substituents and stereochemistry has been synthesized and subjected to carbonylation. The ring expansion to β-lactam takes place in the absence of an electron-withdrawing substituent and higher yields are always obtained for cis-aziridines. Moreover, the regioselectivity of the reaction is affected by the nature of substituents at ring carbon atoms.
