33760-56-4

Upstream product

• 56588-55-7 (+/-)-17c-hydroxy-3-methoxy-13-methyl-(13r)-12,13,16,17-tetrahydro-11H-cyclopenta[a]phenanthrene-15-carboxylic acid methyl ester 
• 56588-57-9 (+/-)-17c-hydroxy-3-methoxy-13-methyl-(13r)-12,13,16,17-tetrahydro-11H-cyclopenta[a]phenanthrene-15-carboxylic acid 
• 17253-36-0 3-O-methyl-estra-1,3,5⁽¹⁰⁾,6-tetraen-17-one 
• 24130-35-6 19-acetoxy-androsta-1,4,6-trien-3,17-dione 
• 95282-98-7 19-acetoxyandrosta-1,4-diene-3,17-dione 
• 2229-26-7 19-acetoxy-androst-4-ene-3,17-dione 
• 510-64-5 19-hydroxy-4-androstene-3,17-dione 
• 56614-59-6 14-dehydroequilenin-3-methylether 
• 6733-79-5 3-methoxyestra-1,3,5(10),8(9)-tetraen-17β-ol 

Downstream Products

• 3907-67-3 3-O-methylequilinine 
• 517-09-9 equilenin 
• 1423-97-8 17β-dihydroequilenin 
• 6639-99-2 17α-dihydroequilenin 

Relevant academic research and scientific papers

Practical semisynthesis of equilenin and its derivatives

Equilenin 2 and its derivatives are important intermediates in the synthesis of steroidal drugs. Until now, these estrogens were produced by extraction from pregnant mare's urine due to the lack of efficient synthetic methods. Most reported semisyntheses of equilenin involve expensive raw materials or toxic reagents to suppress undesired epimerization at C/D ring juncture. Herein, we reported a practical synthesis of highly pure equilenin and its derivatives from an easily available raw material 6 with conventional reagents.