1423-97-8Relevant academic research and scientific papers
Practical semisynthesis of equilenin and its derivatives
Yue, Tao,Li, Hong-Ping,Ding, Kai
, p. 4850 - 4853 (2016/10/07)
Equilenin 2 and its derivatives are important intermediates in the synthesis of steroidal drugs. Until now, these estrogens were produced by extraction from pregnant mare's urine due to the lack of efficient synthetic methods. Most reported semisyntheses of equilenin involve expensive raw materials or toxic reagents to suppress undesired epimerization at C/D ring juncture. Herein, we reported a practical synthesis of highly pure equilenin and its derivatives from an easily available raw material 6 with conventional reagents.
B-ring aromatization of estrogen derivatives
Hylarides,Wilbur,Mettler Jr.
, p. 657 - 662 (2007/10/02)
A noval method of B-ring aromatization of steroid derivatives is reported. Addition of BrCl in methanol to a non-aromatic B-ring double bond results in a rapid double elimination generating the aromatic B-ring. This procedure represents an effective method for conversion of an equilin to an equilenin nucleus.
Steroid ether splitting
-
, (2008/06/13)
Ethers of aromatic steroids are cleaved to regenerate the hydroxy group with aluminum hydride, dialkylaluminum hydride or trialkylaluminum.
