3378-73-2

Basic information

• Product Name: α,α-Diphenyl-N-benzylbenzenemethanamine
• Synonyms: N-Tritylbenzenemethanamine;N-Tritylbenzylamine;α,α-Diphenyl-N-benzylbenzenemethanamine
• CAS NO: 3378-73-2
• Molecular Formula: C₂₆H₂₃N
• Molecular Weight: 349.47
• Mol File: 3378-73-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α,α-Diphenyl-N-benzylbenzenemethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-Diphenyl-N-benzylbenzenemethanamine(3378-73-2)
• EPA Substance Registry System: α,α-Diphenyl-N-benzylbenzenemethanamine(3378-73-2)

Safety Data

• Hazardous Substances Data: 3378-73-2(Hazardous Substances Data)

Usage

General Description

α,α-Diphenyl-N-benzylbenzenemethanamine is a chemical compound with the molecular formula C27H25N. It is a white to light yellow crystalline solid with a molecular weight of 343.49 g/mol. It is also known by the trade name benzphetamine and is used as a prescription medication for the treatment of obesity. It works as a central nervous system stimulant and appetite suppressant, helping to control hunger and aid in weight loss. It is often used in combination with a reduced-calorie diet and exercise program to achieve optimal results. However, it is important to use this medication under the close supervision of a healthcare professional, as it can have potential side effects and interactions with other medications.

Upstream product

• 78646-25-0 4-dimethylamino-1-N-(triphenylmethyl)pyridinium chloride 
• 100-46-9 benzylamine 
• 108-86-1 bromobenzene 
• 76-84-6 triphenylmethyl alcohol 
• 76-83-5 trityl chloride 
• 5824-40-8 Triphenylmethylamin 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 157197-53-0 1,3-di-tert-butylimidazol-2-ylidene 

Downstream Products

• 3287-99-8 benzylamine hydrochloride 
• 100-46-9 benzylamine 

Relevant articles and documents

Temporal control in tritylation reactions through light-driven variation in chloride ion binding catalysis-a proof of concept

Tripodal triazole-linked azo(hetero)arene-based photoswitchable catalysts T1-5 have been designed, synthesized and optimized for the tritylation reaction of benzylamine (BzNH2). The tritylation reaction rates/yields achieved by light induced isomerization are compared between the native and photoswitched states of the catalyst T1. This concept of controlling the tritylation reaction rates with light has also been extended to additional substrates. The critical role of the triazole C-H?Cl- interactions has been confirmed by a combination of spectroscopic, calorimetric and computational studies. Also, the effect of variation in the binding affinities between the native and photoswitched states of the catalyst at room temperature in the temporal control of the catalysis has been demonstrated. This journal is

Stereoselective and Enantiospecific Mono- and Bis-C?H Azidation of Tr?ger Bases: Insight on Bridgehead Iminium Intermediates and Application to Anion-Binding Catalysis

In the context of Tr?ger base chemistry, regio- and stereoselective Csp3?H azidation reactions are reported. Azide functional groups are introduced at either one or the two benzylic positions selectively. Mild conditions and good yields are aff

Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein e production

We have identified a new class of triarylmethyl amine compounds that can inhibit apolipoprotein E (apoE) production. ApoE is a cholesterol- and lipid-carrier protein implicated in aging, atherosclerosis, Alzheimer's Disease (AD), and other neurological and lipid-related disorders. Attenuation of apoE production is generally considered to be of therapeutic value. A majority of the apoE in the brain is produced by astrocytes. Here, we describe the design, synthesis, and biological screening of a small library of compounds that led to the identification of four triarylmethyl amines as potent inhibitors of apoE production in CCF-STTG1 astrocytoma cells.